Figure 1: Gross images and representative photomicrographs depicting various parameters of early stage OSCC. Gross images of total glossectomy specimen showing a grey white ulceroinfiltrative lesion (a and b) and maxillectomy specimen showing a superficial grey brown ulceroproliferative lesion (c) with photomicrographs showing WD (d, H and E ×400), MD (e, H and E ×400), and PD (f, H and E ×400) early stage OSCC; WPOI 1 with pushing borders (g, h and E ×100), WPOI 2 with finger like growth (h, H and E ×400), WPOI 3 with large separate islands showing more than 15 cells per island (i, H and E ×400), WPOI 4 with small tumor islands showing 15 cells or fewer per island (j, H and E ×400), WPOI 5 with tumor satellites >1 mm from main tumor (k, H and E ×40), LHR type 1 (l, H and E ×400) and type 2 (m, H and E ×100), PNI around small (n, H and E ×400) and large nerves (o, H and E ×100), LVI (p, H and E ×100), measurement of DOI (q, H and E ×40) and lymph nodal metastasis (r, H and E ×400). OSCC: Oral squamous cell carcinoma, WD: Well differentiated, MD: Moderately differentiated, PD: Poorly differentiated, WPOI: Worst pattern of invasion, LHR: Lymphocytic host response, PNI: Perineural invasion, LVI: Lympho-vascular invasion, DOI: Depth of invasion