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  Indian J Med Microbiol
 

Figure 3: 100× view: The SPEC 11q gain/loss Triple Color probe is a mixture of a green fluorochrome direct labeled probe hybridizing in the MGR at 11q23.3, an orange fluorochrome direct labeled probe hybridizing in the MLR at 11q24.3, and a blue fluorochrome direct labeled CEN 11 probe specific for the alpha satellite centromeric region of chromosome 11. In a normal interphase nucleus, two green, two orange, and two blue signals are expected. In a cell with amplification at 11q23.3 and deletion at 11q24.3, multiple copies of the green signals and a reduced number of orange signals will be observed

Figure 3: 100× view: The SPEC 11q gain/loss Triple Color probe is a mixture of a green fluorochrome direct labeled probe hybridizing in the MGR at 11q23.3, an orange fluorochrome direct labeled probe hybridizing in the MLR at 11q24.3, and a blue fluorochrome direct labeled CEN 11 probe specific for the alpha satellite centromeric region of chromosome 11. In a normal interphase nucleus, two green, two orange, and two blue signals are expected. In a cell with amplification at 11q23.3 and deletion at 11q24.3, multiple copies of the green signals and a reduced number of orange signals will be observed