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  Indian J Med Microbiol
 

Figure 3: (a) Diffuse strong cytoplasmic ALK immunohistochemistry positivity in tumor cells (×200). (b) ALK break-apart FISH utilizes DNA probes that hybridize to the 3′ (red signal) and 5′ (green signal) regions of the common fusion breakpoint in ALK. ALK rearrangement is identified by splitting of the red and green signals in both nuclei in this field

Figure 3: (a) Diffuse strong cytoplasmic ALK immunohistochemistry positivity in tumor cells (×200). (b) ALK break-apart FISH utilizes DNA probes that hybridize to the 3′ (red signal) and 5′ (green signal) regions of the common fusion breakpoint in ALK. ALK rearrangement is identified by splitting of the red and green signals in both nuclei in this field