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  Access statistics : Table of Contents
   1998| January  | Volume 41 | Issue 1  
    Online since October 12, 2009

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Papillary carcinoma of the male breast diagnosed by fine needle aspiration cytology.
N Joshi, C Pande
January 1998, 41(1):103-6
A 57-year old male presented with a left breast mass, the fine needle aspiration cytology revealed characteristic cytomorphological features of papillary carcinoma of the breast. In our knowledge this is a second reported case of papillary carcinoma of male breast diagnosed by the fine needle aspiration cytology. Cytomorphological and histopathological features of the case are described with literature on cytological features of papillary carcinoma and carcinoma of male breast is briefly reviewed.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  938 49 -
Cytohormonal evaluation of vaginal smears by phase contrast microscopy with special reference to progesterone deficiency pattern during early pregnancy as predictor of abortion.
W Raina, A Batra, S Ranga, S K Das, V H Talib
January 1998, 41(1):85-98
Cytohormonal profile of unstained vaginal smears were studied under phase contrast microscope to define various cell morphologies in detail and build up of smear pattern serially in various stages of menstrual cycle and first trimester of pregnancy. The findings were correlated clinically and found comparable to Papanicolaou stained smears. The maturation index was calculated more objectively by phase contract microscopy because of the refractile appearance of the pyknotic nuclei of superficial cells. The prognostication of abortion was done by combining abnormal maturation index and the presence of syncytiotrophoblasts in vaginal smears. Under phase contrast microscope, the sensitivity of abnormal smear was 87.5%, the specificity was 95%, the positive predictive value was 96.55% and the overall accuracy was 90% as compared to positive Papanicolaou smear whose sensitivity though 93%, had low specificity of 50% only. Phase contrast study appears to offer certain distinct advantage over the conventional light microscopy for quick, comprehensive and quantitative assessment of the study material. It allows the physician to detect changes in the material obtained from the patients without detour of laboratory fixation and staining. It is technically easy as errors in interpretation due to unsatisfactory fixation, staining and artefacts are obviated. Thus phase contrast microscopy offers an alternative and easy method of cytohormonal evaluation of wet and unstained smears.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  822 60 -
Serology and immunoglobulin profile in rheumatoid arthritis.
S Adhya, G Chakraborty, B Hajra, S Bhattacharya, P K Sikdar, S Sinha, P P Banerjee, E Ghosh, P Chakraborty
January 1998, 41(1):43-7
One hundred and twenty cases of clinically diagnosed rheumatoid arthritis, 80 non-rheumatoid cases suffering from various other diseases and 40 healthy individuals were investigated for the presence of rheumatoid factor, quantitation of serum immunoglobulin, demonstration of ANA and LE cell phenomenon. Microlatex agglutination test of serum for rheumatoid factor showed 56.6% positivity in rheumatoid group and 3.7% positivity in non-rheumatoid group. All three serum immunoglobulins (IgG, IgM, IgA) were raised in serum in significant titre in cases of rheumatoid arthritis, whereas only IgA lever was elevated in the group of non-rheumatoid diseases. ANA and LE cell phenomenon were observed in 11.7% and 4.4% cases of rheumatoid arthritis who had severe underlying disease. In non-rheumatoid group, only one of 6 cases of systemic lupus erythematosus showed rheumatoid factor and that too in an insignificant titre (less than 1:20). Synovium and synovial fluid contained plenty of plasma cells and lymphocytes. It has been observed that RF appears first in synovial fluid and it may take several months to a year to attain detectable level in serum.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  796 80 -
A simple device for embalming cadavers.
S Janakiram, V Balasubramanyam, I M Thomas
January 1998, 41(1):39-42
A simple design of a mobile embalming unit is presented that offers better quality embalming and is fairly economical. The technique is faster and consistently more reliable than the conventional gravity aided embalming.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  734 91 -
C-reactive protein and buffy coat smear in early diagnosis of childhood septicemia.
A De, K Saraswathi, A Gogate, K Raghavan
January 1998, 41(1):23-6
Out of 200 cases of septicemia in children (age group 0-14 years), 111 had positive C-Reactive Protein (CRP > 12 mg/l) and 84 were buffy coat smear positive. Blood culture was positive in 98 cases, with predominant organism being Klebsiella pneumoniae, followed by Staphylococcus aureus. CRP test showed 100% sensitivity and 87.3% specificity, while buffy coat smear showed 76.5% sensitivity and 91.2% specificity. As blood culture reports are not available before 48-72 hours, combination of CRP test and buffy coat smear examination will be very helpful in early diagnosis of childhood septicemia.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  718 97 -
Relation of mast cell, nerve and fibrosis in appendix.
R Naik, M R Pai, R Bansal, R Pai
January 1998, 41(1):27-30
The relationship of mast cells, nerves and fibrosis was studied in 50 cases of Appendix using simple histochemical technique. In the mucosa, the mast cell number was greater in the early stages of fibrosis. Both in the mucosa and submucosa mast cells were found closely associated with neural tissue. As the fibrosis increased this association between mast cells and neural tissue was retained only in the submucosa.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  728 67 -
Neonatal hepatitis--an autopsy study of 14 cases.
T M Shet, B M Kandalkar, I M Vora
January 1998, 41(1):77-84
Fourteen autopsy cases of neonatal hepatitis have been studied. Of these seven cases were due to infections viz.: cytomegalovirus infection (four cases), probable cases of congenital syphilis (two cases) and neonatal herpes (one case). The remaining seven cases were of Idiopathic Neonatal Hepatitis (INH) with giant cell change in six cases. Even in these cases (INH) there was a high index of suspicion of intrauterine or acquired infection in view of severe mononuclear inflammation in the pancreas, alimentary tract and lungs. Most of these neonates with INH had low birth weight and two were preterm pointing towards a prenatal insult. The orcein stain and Periodic Acid Schiff (PAS) with diastase in all the cases were negative making hepatitis B virus infection and infinity 1 antitrypsin deficiency less likely. These autopsies represent the tip of the iceberg and only the severe cases of infection. The fatal outcome could have been prevented by maternal screening for infections and earlier clinical diagnosis.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  724 67 -
A study on opportunistic enteric parasites in 80 HIV seropositive patients.
S H Talib, J Singh
January 1998, 41(1):31-7
AIDS is characteristically associated with several opportunistic enteric protozoal infestations that cause chronic and at times fatal diarrhoeas. A study is undertaken to isolated opportunistic enteric parasites in 80 HIV seropositive patients. An attempt is made to correlate and signify the presence of coexistent oral candidosis and enteric pathogens.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  696 88 -
Intraperitoneal abscess in a new born secondary to Klebsiella septicaemia--a case report.
P G Kumari, P L Rao, B Antony, P G Shivananda
January 1998, 41(1):101-2
A five day old female baby was admitted with distension of abdomen since birth and nonbilious vomiting, fever of one day duration. Blood culture grew Klebsiella pneumoniae. Abdominal exploration revealed thick walled cavity containing purulent fluid grew klebsiella pneumoniae which was sensitive to various antibiotics including gentamycin. The child was treated with injection gentamycin and ceftazidime. The child had uneventful recovery and is doing well 3 years post operatively.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  739 25 -
Autopsy study of patients dying of bleeding diathesis.
S Bhatia, N Ranadive, R Manek, K Deodhar
January 1998, 41(1):71-6
Ten thousand & thirty seven autopsies performed from the year 1982 to 1992 were studied retrospectively, to find out the number of deaths due to bleeding diathesis. Eighty-seven (0.87%) patients died due to bleeding diathesis, out of which haemolytic uraemic syndrome (HUS) was seen in 9 cases (10.34%), disseminated intravascular coagulation (DIC) in 67 cases (77.01%) & 11 cases were grouped as miscellaneous. Martius scarlet blue stain was carried out to demonstrate fibrin & depending on the number of thrombi in the glomerulus & blood vessels, the lesions were graded as mild, moderate or severe. Kidney was the most common organ involved in all groups of bleeding diathesis. In DIC kidney & lung involvement was almost equal.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  717 41 -
Neurofibromatosis of the colon : an unusual manifestation of von Recklinghausen's diseases--a case report.
S Jacob, B R Prabhakar, S K Singh, K J Mammen
January 1998, 41(1):113-6
Multiple neurofibromas arising in nerves are well established features of von Recklinghausen's disease. However, significant involvement of the gastrointestinal tract, especially the colon, is a rare entity. We hereby report a case of colonic neurofibromatosis.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  706 42 -
Blood glucose and ischemic brain damage.
N Islam, M Aftabuddin, A Moriwaki, T R Koirala, Y Hori
January 1998, 41(1):15-22
The effect of hyperglycemia on ischemic brain damage was studied in a rat model of incomplete ischemia. Incomplete ischemia was produced by permanent occlusion of one (either left or right) common carotid artery (CCA). Hyperglycemia was induced by intraperitoneal injection of 50% glucose, and same volume of physiological saline was injected in the controls 40 min before CCA ligation. Serum glucose level, at the time of vessel ligation, was 33.3 mMol/L. After CCA ligation, the rats were allowed to wake up and survive for upto 1 month. Perfusion-fixed brains were embedded in paraffin, subserially sectioned, and stained with haematoxylin-eosin/cresyl violet. Brain from sham-operated animals showed no damage neurons. Only mild neuronal damage was observed in saline pre-treated rats in CA1 area. Histological examination 24 h after CCA occlusion revealed ischemic neuronal cell damage to be more extensive in hyperglycemic rats. Neuronal damage was found in the major brain structures vulnerable to several insults. Some of those damaged neurons recovered well, but presence of some damaged neurons at 1 month of recovery suggesting delayed recovery. The results indicate that increased blood glucose level (hyperglycemia) during brain ischemia exaggerates structural alterations and leads to delay in recovery.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  719 27 -
The role of Gardnerella vaginalis in nonspecific vaginitis in intra uterine contraceptive device users.
B K Gupta, R Kumar, R Sofat, S Khurana, Deepinder
January 1998, 41(1):67-70
Two Hundred Forty patients who had Intra Uterine Contraceptive Device (IUCD) and manifested of nonspecific vaginitis were investigated for the presence of G. vaginalis. Pure growth of this organism was obtained in 14(5.8%) cases while 116(48.3%) cases showed this organism in association with other organisms e.g. Esch. coli (11.7%), Klebsiella (9.2%), Candida (9.2%), Strept. faecalis (7.3%), Proteus species (5.8%) and Staph. albus (5%).
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  654 81 -
Enhanced detection of herpes simplex virus from ocular specimens of herpetic keratitis patients.
N P Pramod, V Gopalakrishnan, R Mohan, S Chandriga, K Anandakannan, T Menon, S P Thyagarajan
January 1998, 41(1):49-53
Corneal scrapings collected from 70 patients were used to assess the diagnostic value of indirect immunofluorescence (indirect IF) procedure in comparison with routine virus culture (RVC) for the diagnosis of Herpes simplex virus induced keratitis (HSK). Virus specific antigen was detected by indirect IF in 22 (31.42%) cases. In contrast, only 20% (14) of the cases had positive viral isolation which sometimes took as long as a week to show a cytopathogenic effect (CPE). It is concluded that antigen detection by indirect IF is a rapid, specific and sensitive technique for demonstrating HSV-1 antigen in corneal scrapings from HSK patients and a useful laboratory tool not only for diagnosing HSK but also for monitoring efficiency of anti HSV treatment for HSK.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  686 44 -
Multiple primary visceral malignancy--a review with report of two cases.
K B Logani, P Bajaj, J Mukherjee, S M Gulati, S Thomas, B S Baliga, S Khanna
January 1998, 41(1):107-11
Multiple primary cancers are being reported with increasing frequency in recent years, the frequency varying from 0.3 to 4.3% in different studies. A combination of primary cancer of larynx and lung is the most common followed by malignant neoplasm involving lip-larynx, skin-larynx, skin-lung, breast-ovary and breast-endometrium. Two interesting cases of rare combinations of primary cancers are being presented. In the first case primary adenocarcinoma of the gall bladder was associated with appendiceal adenocarcinoma. In the second case primary malignant papillary serous cystadenocarcinoma of right ovary and squamous cell carcinoma of cervix uteri were found.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  685 32 -
A, B & H isoantigens in cervical lesions.
D Bisht, V Misra, S C Gupta, R Mehrotra, S Garg
January 1998, 41(1):11-4
Expression of A, B and H isoantigens in cervical mucosa was demonstrated by specific red cell adherence test in 92 cervical lesions (40 chronic cervicitis, 12 dysplasia and 40 carcinoma cervix). Eighty percent cases of chronic cervicitis showed a moderate reaction. On the contrary, in carcinoma cervix, 75% cases were found to be SRCA negative. In dysplasia, the intensity of red blood cell adherence was found to be directly related to the degree of cellular differentiation. Study of A, B and H isoantigens might help in deciding the prognosis of dysplasia and/or early detection of malignancy.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  677 31 -
Changing patterns and re-distribution of antigen in poorly differentiated carcinomas : its implications in tumour diagnosis.
S Pervez, S H Hasan, F Aijaz, S A Aziz, Y Amirali, H Shaikh
January 1998, 41(1):55-66
The variability of expression of tumour-associated antigens via either antigenic heterogeneity or antigenic modulation presents a basic problem in immunohistochemical diagnosis of poorly/undifferentiated tumours. This work was designed to study antigenic expression on human resected epithelial tumours by a panel of most widely used antibodies (EMA, CEA, AUAI & Cytokeratin) in relation to tumour differentiation and polarization. It was observed that poorly differentiated carcinoma with loss of polarity show homogeneous membrane staining (with antibodies against EMA, CEA & AUAI) in contrast to either apical (luminal) or basolateral membrane staining in well differentiated counterparts. Biochemical studies have shown that apical and basolateral epithelial cell membrane domains have a characteristic set of glycoproteins. Tight junctions are essential for maintaining this functional polarization. It was concluded that structural and functional abnormalities of tight junctions in poorly differentiated carcinomas results in loss of polarity with progressive invasion of the cell surface by antigenic glycoprotein and resultant homogeneous individual cell antigenic expression in poorly differentiated carcinomas. This study demonstrates that antigenic expression on tumour cells is not static, but dynamic and heterogeneity of antigenic expression may well be due to biological factors such as spatial configuration of the lesion.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  577 26 -
Mitochondrial myopathies--a clinicopathological study.
V V Radhakrishnan, A Saraswathy, N S Radhakrishnan, M D Nair, A Kuruvilla, K Radhakrishnan
January 1998, 41(1):5-10
Mitochondrial myopathies are heterogeneous group of clinical disorders that can affect multiple systems besides skeletal muscles. The mitochondrial abnormalities in the skeletal muscles are morphologically identified by the presence of characteristic Ragged-red fibers (RRF) in the cryostat sections of the muscle stained with modified Gomori's trichrome stain. In this retrospective study, clinical and histopathological features in six patients with mitochondrial myopathies have been analysed. The utility of histochemical methods in confirming the diagnosis of mitochondrial myopathy has been emphasised.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  545 55 -
Anti tubercular activity of garlic oil.
R C Jain
January 1998, 41(1):131-131
Full text not available  [PDF]  [PubMed]
  377 86 -
Troponin--a promising marker for myocardial injury.
S Ranga, N Trivedi, S K Khurana, V H Talib
January 1998, 41(1):117-30
Full text not available  [PDF]  [PubMed]
  334 47 -
Aspiration cytologic diagnosis in clinically unsuspected leprosy--a case report.
S Jain, D Basu, K U Chaturvedi
January 1998, 41(1):99-100
Full text not available  [PDF]  [PubMed]
  344 34 -
Communicable diseases and fifty years of independence.
S K Shahi, S K Khurana, S Ranga, V H Talib
January 1998, 41(1):1-3
Full text not available  [PDF]  [PubMed]
  335 26 -
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