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   1997| January  | Volume 40 | Issue 1  
    Online since October 12, 2009

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Early diagnosis of bone biopsies--the role of sediment cytology.
M Valiathan, J Augustine, B Prasanna, V G Chellam
January 1997, 40(1):17-20
This study analyses the role of the cytological examination of the sediment of the formalin in which bone biopsy specimens are received, in the early diagnosis of bone lesions. Of the one hundred lesions studied using this technique, twenty six of thirty three malignant lesions (seventy nine percent) could be diagnosed as malignant when relevant clinical and radiological data were considered. Sixty six benign lesions yielded sparsely cellular smears with benign cell. There was one false positive for malignancy. This simple rapid diagnostic technique can be used to advantage in the early diagnosis, and treatment planning of bone lesions.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  821 95 -
Evaluation of luteal phase in normal and infertile women.
M John, K Rameshkumar, D A Lillian
January 1997, 40(1):27-31
Evaluation of luteal phase function is an important part of fertility evaluation in the female. Among fifty clinically identified patients with primary infertility certain well-established laboratory methods were used to identify the luteal phase defect. These methods included serum progesterone assays, endometrial biopsy, vaginal cytology, basal body temperatures and cervical mucus scoring, with appropriate controls. Based on both endometrial biopsy which was two or more days out of phase and the serum progesterone level of less than 2.5 ng/ml, luteal phase defect was found in five patients among the 50 patients (10 percent). It was found that an endometrial biopsy which was well dated showed a definite correlation with the progesterone assays and could be considered as the most easily performed and reliable indicator, useful in detecting a luteal phase defect.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  805 99 -
Chediak-Higashi syndrome--a case report with ultrastructural and cytogenetic study.
T S Yasha, S Vani, A Vasanth, M Augustus, Y Ramamohan, S Das, S K Shankar, R C Yasha
January 1997, 40(1):75-9
We report the ultrastructural abnormalities of the leukocyte granules and the cytogenetic findings in a patient of Chediak-Higashi syndrome (CHS), who presented with cutaneous melanosis as the only clinical feature. The diagnosis of CHS was established by peripheral smear and bone marrow examination. Chediak-Higashi syndrome, a rare autosomal recessive disorder is characterized by enlarged abnormal organelles in leukocytes and other cells. An interesting aspect of our patient was the absence of recurrent infections or any other clinical stigmata. Ultrastructurally, the leukocytes and their precursors in the bone marrow showed characteristic homogenous and heterogenous giant inclusions of variable sizes and shapes. These represent the primary granules which enlarge to attain the giant abnormal size by fusion with other primary or secondary granules. Cytogenic study of the bone marrow cells showed monosomy of chromosomes 8 and 17 in 20 percent of the metaphases. Neither the gene nor the chromosomal abnormalities specific for CHS have been identified as yet and thus the significance of our cytogenetic finding is presently not clear.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  848 38 -
Nephrogenic adenoma of the ureter--a case report.
T R Koirala, M Aftabuddin, H L Chen, N Islam, T Ishimastu
January 1997, 40(1):61-2
We present a case of nephrogenic adenoma, a rare benign lesion arising from the ureter. Histologically, it showed the formation of epithelial lined tubules resembling the renal tubules. Special Stain demonstrated the presence of intraluminal PAS-positive materials.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  827 25 -
Subcutaneous and osteolytic rhinosporidiosis.
S Gokhale, V C Ohri, H Subramanya, P S Reddy, S C Sharma
January 1997, 40(1):95-8
A young man presented with multiple Subcutaneous nodules over scalp, hand, feet and osteolytic lesions of small bones of hand. Clinically and radiologically he was diagnosed as a case of Giant Cell Tumour. Aspiration cytology and biopsy proved it to be rhinosporidiosis. Epidemiological study revealed that he perhaps contracted this infection as an occupational hazard. This is the third reported case of osteolytic lesions due to rhinosporidiosis. Diagnostic dilemmas of subcutaneous and osteolytic rhinosporidiosis are discussed.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  765 70 -
Retinoblastoma--a histologic and immunohistologic study.
R Arora, S M Betharia
January 1997, 40(1):37-46
Histopathology and various immunohistochemical markers were studied in 40 cases of human retinoblastoma. In histopathology, tumour type, extent and invasion were studied. In immunohistochemistry, both glial and neural markers were used to know the histogenesis of this tumour. The glial markers, glial fibrillary acidic protein and vimentin, were detected in retinal astrocytes and Muller's cells in normal retina and perivascular glia in retinoblastoma. The neural marker, neurone-specific enolase stained neurones in outer and inner nuclear layers in normal retina, Flexner-Wintersteiner rosettes in retinoblastoma and tumour cells is differentiated retinoblastoma. Another neural marker, neurofilament triplet polypeptide stained neurones in inner nuclear layer of normal retina and Flexner-Wintersteiner rosettes in well-differentiated retinoblastoma. These results support the view that retinoblastoma has predominantly neuronal origin.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  769 59 -
Correlation of the growth fraction, nucleolar organizer region counts and epidermal growth factor receptor with histomorphological prognostic criteria in breast cancer.
G R Gupta, B N Datta, S M Bose, K Joshi
January 1997, 40(1):3-10
A total of 60 cases of breast cancer were studied to find the correlation between newer parameters of prognosis viz growth fraction (GF), nucleolar organizer region (AgNOR) counts and epidermal growth factor receptor (EGFR) positivity with the various histomorphological factors such as tumour size, nuclear grade, histological grade and mitoses. Growth fraction measured by Ki67 monoclonal antibody varied from 3.6 to 73.7 percent. AgNOR counts ranged from 1.2 to 16.9 dots per tumour cell nucleus with a mean of 6.26 dots. EGFR positivity was seen in 66.7% of cases. Ki67 score correlated with all prognostic variables studied except the presence of axillary metastases. AgNOR counts correlated with size of tumour, axillary lymph-node metastases and Ki67 score but no correlation was seen with histologic or nuclear grade. EGFR positivity correlated strongly with size of the tumour and weakly with Ki67 score, AgNOR counts and mitoses.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  794 33 -
T cell rich and histiocyte rich B cell lymphoma--a case report.
A Rajwanshi, A K Banerjee, Y K Chawla
January 1997, 40(1):85-9
We report one case of Non Hodgkin's Lymphoma which was classified as Histiocyte Rich B cell lymphoma on immunocytochemistry. The diagnosis was difficult on fine needle aspiration cytology and routine histopathological examination as the infiltrate was composed of reactive lymphocytes and numerous histiocytes obscuring the lymphoma cell population. The neoplastic cells were positive for CD20(L26-A Pan B marker) and negative for CD15(Leu M1), CD3(Ber H2) and pan T cell markers. The histiocytes were positive for CD3(UCHL-1). The patient had a rapid downhill course and died. The autopsy showed infiltration in the axillary, cervical, mesenteric, para aortic, peri pancreatic and hilar lymph nodes. The liver, spleen, bone marrow and kidney also showed lymphomatous infiltration.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  788 35 -
A simple synthetic liquid medium for development of yeast and mycelial form of pathogenic species of Candida.
P Prakash, A Solanki, K R Joshi
January 1997, 40(1):55-8
Thirty two known strains of Candida species were used for evaluation of glucose, serine, ornithine, methionine, GSOM medium and its comparison with Lee's medium for the production of yeast and mycelial phase at different temperatures and on prolonged incubation. No mycelial form was observed when various Candida species in GSOM and Lee's medium were incubated at 25 degrees C up to 72 hours. Percentage of mycelial forming cells of Candida species were more in GSOM medium than Lee's medium in 48 hours at 37 degrees C. Among various species of Candida, albicans and C. parapsilosis showed maximum mycelium formation. GSOM medium can be used for growing Candida species particularly C. albicans in mycelial phase.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  749 50 -
Role of redchilli (Capsaicin) in the formation of colonic carcinoma.
S Chitra, P Viswanathan, N Nalini, K Sabitha, V P Menon
January 1997, 40(1):21-5
The effect of feeding redchilli (Capsaicin) powder on the histopathological changes occurring in the colonic mucosa was studied in rats. These animals were compared with those treated with a colonic carcinogen 1,2-dimethylhydrazine (DMH). Animals fed with redchilli, dimethylhydrazine, dimethylhydrazine plus redchilli powder showed polyp and dysplasia, malignant tumour and malignant tumour with transitional area of dysplasia.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  742 47 -
Inherited factor X deficiency in two brothers.
S Barik, A Budhraja, M Bhalla, S Diwan
January 1997, 40(1):63-5
Two brothers born to same parents were diagnosed with inherited factor X deficiency of severe type. Clinical presentation in both the cases were haemarthrosis. The elder brother was diagnosed in the year 1991 when he was four and half years old. Recently the youngest child in the family also presented with haemarthrosis at age of one and half years. Diagnosis was made by abnormal results of Coagulation factors screening mainly Prothrombin time, Activated partial thromboplastin time, Russell's viper venom test, mixing tests factor X assay. Both the brothers had Factor X activity less than one percent.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  751 36 -
Cultivation of Mycobacterium tuberculosis from pleural tissue and its histopathology in suspected cases of tuberculous pleural effusion.
S K Katiyar, R P Singh, K P Singh, G C Upadhyay, A Sharma, L K Tripathi
January 1997, 40(1):51-4
The majority of idiopathic pleural effusion are considered to be of tuberculous etiology. The culture of bacilli provide most authentic evidence of disease process. This study was carried out on 21 cases of suspected tuberculous pleural effusion. The pleural fluid and tissue was subjected for smear examination, and cultivation of tubercle bacilli along with pleural biopsy. Overall the diagnosis could be made out of 8 (38.09%) cases. The cultivation of Mycobacterium tuberculosis from pleural tissue was more sensitive (33.33%) as compared to histopathology (19.05%). However, the triad of cultivation of Mycobacterium tuberculosis from pleural tissue, pleural histopathology and pleural fluid smear examination or culture should be done in each suspected case of tuberculous effusion.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  704 46 -
Proliferating cell nuclear antigen immunostaining in breast carcinoma and its relationship to clinical and pathological variables.
S Agarwal, R Jain, U Rusia, R L Gupta
January 1997, 40(1):11-6
Tumour proliferative activity of 74 breast lesions was assessed by determining mitotic index and immunostaining for proliferative cell nuclear antigen using Peroxidase antiperoxidase method. The indices were correlated with histomorphology and clinical stage of the disease. Positively stained nuclei and mitotic figures were counted per 1000 cells to calculate Proliferating Cell Nuclear Antigen (PCNA) and mitotic index respectively. Sixty four cases stained positive for PCNA. The index ranged between 0 to 98. PCNA index was significantly low in benign lesions as compared to malignant lesions (p < 0.0002). There was a linear correlation between the mitotic index and PCNA index. PCNA index also showed significant correlation with tumour size and histologic grade; however, it had no correlation with axillary lymph node status.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  710 38 -
Study of cryptosporidiosis in a rural area of Maharashtra.
H Khubnani, K Sivarajan, A H Khubnani
January 1997, 40(1):33-6
Human cryptosporidiosis has been reported world wide, both from developed and developing countries and from urban and rural areas. Present study is undertaken to assess the occurrence of cryptosporidiosis in human and cattle population (cows and calves) in and around the rural areas of Loni, district Ahmednagar, Maharashtra State. Human stool samples were collected from 220 patients of age ranging between newborn to 85 years, attending the Pravara Rural Hospital, Loni. The samples were examined using modified Ziehl-Neelsen staining technique. Drug samples were also examined from 101 asymptomatic (apparently healthy and non-diarrhoeic) cows and calves from the same area, to detect Cryptosporidium. Three positive cases (1.36%) in human and 11 positive cases (10.89%) in cattle (cows and calves) were detected. It is assumed that in rural areas the most likely source of human infection is cattle. This is the first report of human infection by Cryptosporidium from rural Maharashtra and also the first report of occurrence in cattle from India.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  677 67 -
Haemolytic Escherichia coli in etiopathogenesis of pyelonephritis in rats--an experimental study.
S L Akulwar, A M Kurhade, A M Saoji
January 1997, 40(1):47-9
Of the 26 urinary E. coli strains employed in the present study, 16 were haemolytic and 10 were non haemolytic in character. Of the 16 haemolytic strains injected through the exposed femoral vein of the rats, 12 showed the lesions of pyelitis, pyelonephritis and proliferation of glomerular tuft while 2 showed only the lesions of pyelitis and pyelonephritis. It was interesting to note that none of the nonhaemolytic strains produced any lesion in the animal. The data demonstrated a positive correlationship between haemolytic activity of E. coli and pyelonephritis in rats.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  700 37 -
Fine needle aspiration cytology in the diagnosis of mediastinal seminomas.
A Mondal, S Mittra, D Mittra, S Banerjee
January 1997, 40(1):59-60
Fine needle aspiration cytology (FNAC) was employed to diagnose 117 cases of mediastinal tumours from January, 1985 till December, 1994. Six cases were diagnosed as mediastinal seminomas which are rare mediastinal malignant neoplasms. All patients had complete resolution of the mediastinal masses after external beam radiotherapy. Diagnosis of mediastinal masses by FNAC can spare the patients from more invasive diagnostic procedures and help the thoracic surgeons to plan immediate treatment.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  698 39 -
Malignant interstitial (Leydig) cell tumour of the testis--a case report.
K K Deodhar, K N Naresh
January 1997, 40(1):67-9
Interstitial (Leydig) cell tumour of the testis is an extremely uncommon tumour. We report one such tumour displaying histologic features of malignancy--large size capsular invasion and moderate nuclear pleomorphism in an adult male. The tumour also showed crystalloids of Reinke, confirming Leydig cell origin.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  701 19 -
Granular cell tumour (choristoma) of the neurohypophysis--a report of two cases.
V V Radhakrishnan, B K Misra, D Rout
January 1997, 40(1):71-4
Granular cell tumours of the neurohypophysis are uncommon and only 30 cases are documented in the literature till 1994. In this communication, the salient clinical and histomorphological features in two patients with granular-cell tumour of the neurohypophysis are described.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  656 44 -
Inflammatory pseudotumour of liver--a case report.
A Gosavi, S Agashe, M Phansopkar, S S Jadhav, B R Agrawal
January 1997, 40(1):81-3
A rare case of inflammatory pseudotumour of liver in a child is reported. The child presented with obstructive jaundice and was considered to have malignant tumour of liver clinically and by imaging modalities. Resection of left hepatic lobe with the mass was done. Histologically, the lesion consisted of an admixture of proliferation of lymphocytes, plasma cells and fibroblasts along with vasculitis and variable amount of hyaline fibrosis. Adjacent liver showed evidence of biliary cirrhosis and multiple microabscesses. Many of the previously reported cases were also diagnosed clinically and radiologically to be malignant tumours of liver. The case is reported to create awareness of this rare entity.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  669 23 -
Dysembryoplastic neuroepithelial tumour of the central nervous system--a case report.
V V Radhakrishnan, B K Misra, B Rao, D Rout
January 1997, 40(1):99-102
Dysembryoplastic neuroepithelial tumour (DNT) of the central nervous system is a recently recognized entity. We describe the clinical and characteristic histomorphological features in a patient with DNT. As this lesion carries a favourable prognosis, it becomes essential to make an accurate histopathological diagnosis.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  596 29 -
Dengue haemorrhagic fever : an overview.
S Ranga, I Prakash, Y Choudhry, A Thergaonkar, S K Khurana, V H Talib
January 1997, 40(1):103-17
Full text not available  [PDF]  [PubMed]
  417 163 -
Dengue : the killer.
V H Talib, S K Verma, J S Dhupia
January 1997, 40(1):1-2
Full text not available  [PDF]  [PubMed]
  413 56 -
Ectopic decidua in association with adenomyosis presenting as fibroids in pregnancy--a case report.
J Agarwal, J K Gupta
January 1997, 40(1):91-3
Full text not available  [PDF]  [PubMed]
  402 42 -
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