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   1996| October  | Volume 39 | Issue 4  
    Online since October 12, 2009

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Adjuvant effect of DEAE-dextran and tetanus toxoid on whole cell heat inactivated phenol preserved typhoid vaccine.
J Kaistha, J Sokhey, S Singh, S Kumar, P C John, N C Sharma
October 1996, 39(4):287-92
Active mouse protection test (AMPT) and enzyme linked immunosorbent assay (ELISA) were used to determine the immunogenicity of whole cell typhoid vaccine when administered in conjunction with either tetanus toxoid (TT) or DEAE-Dextran (DD). Immunization of mice with whole cell typhoid vaccine showed enhanced potency either when administered in conjunction with TT or DD and values were statistically significant (p < 0.05) in comparison to conventional or standard typhoid vaccines. For ELISA, the mice were immunized with 2 different schedules, one in which a single dose of 0.25 ml subcutaneously (s/c) was administered and in another two doses of 0.25 ml each s/c, 14 days apart. In case of single dose schedule of immunization D vaccine (Whole cell typhoid + 5 mg/ml DD) showed significant increase of immune response (3.201 log10) as compared to plain vaccine (2.550 log10). Two dose schedule further increased the titres to 3.856 log10. DD adjuvanted vaccine showed higher potency by AMPT as compared to the TT adjuvanted vaccine or plain vaccine. The present study clearly demonstrates that a single dose of 0.25 ml which is equivalent to half of the conventionally used single human dose of typhoid vaccine adjuvanted with DD can significantly improve the immunogenicity of the vaccine.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  831 49 -
Argyrophilic nucleolar organizer regions in soft tissue tumors.
H L Arora, N Arora, R L Solanki
October 1996, 39(4):257-63
Argyrophilic nucleolar organizer region (AgNOR) staining was employed on 51 apparently normal representative soft tissues, 53 benign soft tissues tumors and 52 malignant soft tissue tumors with an aim to study the sensitivity and specificity of method in differentiating between the benign and malignant soft tissue tumors. The mean AgNORs count in apparently normal fibrous tissue was 1.02, whereas it was 0.94 in adipose tissue, 1.14 in smooth muscle tissue, 1.115 in skeletal muscle tissue, 1.025 in blood vessels endothelial lining cells and 1.04 in nerve tissue. The mean AgNOR count was found to be higher in benign soft tissue tumors as compared to respective apparently normal soft tissue and was found to be statistically significant. The mean AgNOR count in soft tissue sarcomas was found to be higher as compared to both apparently normal soft tissue and benign soft tissue tumors. An increase AgNOR score in both benign and malignant soft tissue tumors as compared to apparently normal soft tissue indicates high proliferative activity. The neurofibrosarcoma showed low AgNOR count as compared to other soft tissues sarcomas. The fibrohistiocytic sarcoma, leiomyosarcoma and angiosarcoma showed a mean AgNOR score of 4 or more than four. The mean AgNOR score was found to increase with high grade of the tumor. The AgNOR staining is simple and useful method in estimating tumor cell proliferation thereby differentiating normal soft tissue from non-neoplastic proliferative growth, benign and malignant soft tissue tumors. It may help in differentiating fibromatosis from fibrosarcoma, dermatofibrosarcoma protuberans of low grade malignancy from high grade malignant fibrous histiocytoma and benign hemangiopericytoma from malignant hemangiopericytoma.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  738 109 -
Cytology of cystitis cystica glandularis of the bladder--a case report.
K Kapila, K Verma
October 1996, 39(4):303-5
The cytologic findings of cystitis cystica glandularis--a form of proliferative cystitis which can be mistaken for a tumor clinically and radiologically have hardly been recorded. We describe a case of cystitis cystica where the bladder washings showed a spectrum of findings which were later corroborated on biopsy.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  743 93 -
Current status of transfusion medicine in India.
Z S Bharucha
October 1996, 39(4):333-42
A review of current scenario of transfusion medicine (TM) in India indicates an urgent need for restructuring the blood transfusion service (BTS). The BTS is hospital based with extreme variations in management and technology in different parts of the country. Compliance of quality assurance and good manufacturing practice is not ensured at all centres. Inspite of compulsory legislation, 34% of blood banks are yet unlicensed. Nearly 50% of 3 million units collected annually against a requirement of 6 million are estimated to be provided from paid blood sellers. Only 5% of voluntary donors are repeat donors. Complete testing of all donated blood is questionable due to operational problems. Only 40 centres are equipped to provide blood components. The shortage of blood is enhanced by inappropriate use of blood. Efficient clinical practice demands introduction of TM as a specialty.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  699 134 -
Haematuria : glomerular or non-glomerular?
R Singbal, B V Mittal
October 1996, 39(4):281-6
The standard urinary sediment of 80 consecutive patients with significant haematuria admitted at our hospital was examined for significantly dysmorphic red blood cells by 3 methods-1. Phase contrast microscopy, 2. Wright's staining of the urinary sediment, and 3. Simple light microscopy. The results of the study were compared with the final diagnosis reached in the ward and the sensitivity of the three methods was statistically compared. Our study conclusively proves that phase contrast microscopy is superior to light microscopy of plain or Wright's stained urinary sediment, with respect to both sensitivity and percentage of dysmorphism of the urinary red blood cells which can be detected.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  700 127 -
Peripheral odontogenic fibroma with chondroid differentiation.
R Sen, K Kalra
October 1996, 39(4):313-5
An unusual case of peripheral odontogenic fibroma, presenting as a swelling on gingiva involving hard palate in a 3-year-old female child, is described. Even with cellular stroma and unencapsulation these tumors behave in a benign fashion. To the best of our knowledge, cartilagenous differentiation of stroma as observed in this case has not been reported in English literature so far.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  713 113 -
Metastatic carcinoma involving the testes.
M C Sharma, K Sudha, M K Singh, R Chahal, R Sood
October 1996, 39(4):293-6
Metastatic carcinoma to testis is an extremely rare but interesting phenomenon. Over a period of nineteen years 300 testicular tumors were diagnosed in our department, and of which 10 were metastatic carcinoma from other sites. Four of these patients (40%) presented as testicular lump of which two were already diagnosed cases of squamous cell carcinoma larynx and adenocarcinoma of lung, and two had occult primary in the kidney and colon. However six (60%) were detected incidentally in the orchiectomy done as a part of hormonal therapy for carcinoma prostate.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  747 60 -
Pleomorphic xanthoastrocytoma.
M R Pai, H Kini, C V Raghuveer
October 1996, 39(4):329-31
Pleomorphic xanthoastrocytoma is an unusual brain tumour of children with a favourable prognosis. The tumour takes origin from subpial astrocytes of the cerebral cortex. Histologically proliferation of spindle cells, mono and multinucleated giant cells containing lipid droplets and the absence of necrosis are distinctive features. Herein we report the morphological and immunophenotypical features of a case of pleomorphic xanthoastrocytoma.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  722 61 -
Serum alpha-1-antitrypsin in ischemia and rheumatic heart diseases.
G L Somayajulu, P P Reddy
October 1996, 39(4):271-5
Tissue damage, inflammation and necrosis are hallmarks of myocardial infarction. In the present study significant elevations of serum alpha-1-antitrypsin were noted in coronary artery disease and angina cases. Interestingly chronic rheumatic heart disease which is also characterized by tissue injury. Inflammation revealed normal levels of serum alpha-1-antitrypsin. The level in chronic rheumatic heart disease was 3.37 +/- 0.57 mumol/mt/ml (control level was 3.37 +/- 0.54 mumol/mt/ml). The corollary of these observations is that in heart diseases acute phase response in terms of enhanced levels of alpha-1-antitrypsin differ depending on the causative factors. Except chronic rheumatic heart disease, in all other stressful states studied there is (to a certain degree) an altered systemic homeostasis and haemostasis. On the other hand chronic rheumatic heart disease encompass certain amount of acute phase status in terms of tissue damage and inflammation does exist unaccompanied by altered systemic homeostasis and haemostasis. However, bacteriological etiologies predominate the triggered immune responses. It is hypothesised that serum alpha-1-antitrypsin enhancement will not occur even though acute phase state exists if specific immune responses are also a part of the disease manifestation.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  694 54 -
Primary synovial chondromatosis--a case report.
Z Patvegar, P Muley, S Deshpande
October 1996, 39(4):317-9
Synovial chondromatosis are rare tumours encountered in hip, knee and shoulder joints. Synovial chondromatosis at metatarso-phalangeal joints are still rarer. Herein is reported a case of primary synovial chondromatosis of metatarsophalangeal joint in 54-year-old male. A brief review of previous published articles has been dealt herewith.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  642 91 -
Case report of intramuscular myxoma with review of literature.
N Calton, R Isaacs, B R Prabhakar
October 1996, 39(4):299-301
This is a case report of a lady who presented with mass in the abdominal wall, clinically diagnosed as neurofibroma. On histological examination it was proven to be an intramuscular myxoma. Since it is rare it was thought relevant to report this case.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  629 88 -
Haemangiopericytoma of the nasal cavity.
S Mangwana, S P Batra, L R Pathak
October 1996, 39(4):311-2
Haemangiopericytoma of nose and paranasal sinuses is relatively uncommon tumour. It occurs in adults in sixth and seventh decades of life. In view of paucity of intranasal haemangiopericytoma old in Indian literature and young age of patient, we are reporting one case in 28-year-old female who presented with recurrent, profuse epistaxis.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  630 65 -
Role of fine needle aspiration cytology in diagnosis of malignant scalp and underlying bone tumours.
A Mondal, C K Ray
October 1996, 39(4):265-9
Fine needle aspiration cytology (FNAC) was employed in 183 cases of clinically malignant scalp and underlying bone tumours from July, 1984 to December, 1994. The age of the patients ranged from 2 years to 89 years. There were 68 benign and 115 malignant lesions. Only the malignant lesions are analysed in the present series. The cytological findings correlated with the histopathological analysis in 94.7% of cases. There was no false positive report. The cytological analysis helped the neurosurgeons to arrive to a quick pre-operative diagnosis which help early treatment avoiding open surgical biopsy in this vital area. Very scanty literature is available on FNAC of this region.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  602 80 -
Parathyroid cyst--a rare case report.
R R Pai, R Verghese, K R Pai, R Naik
October 1996, 39(4):297-8
A rare case of parathyroid cyst in a forty six-year-old lady diagnosed clinically as solitary thyroid nodule is reported. An intra-operative diagnosis of parathyroid cyst was made which was confirmed histopathologically. The clinicopathologic aspects, diagnostic methods and treatment modalities of this unusual condition are briefly discussed.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  617 48 -
Evaluation of HBsAg carrier rate in acute viral hepatitis and high risk individuals using RPHA and ELISA.
A Korgaonkar, M P Verenkar, R Savio, M J Pinto, I Singh
October 1996, 39(4):277-80
A total of 600 individuals including 500 cases of hepatitis and 100 individuals at high risk for developing hepatitis were screened for hepatitis B surface antigen (HBsAg) using reverse passive haemagglutination (RPHA) and enzyme linked immunosorbent assay (ELISA). HBsAg carrier rate in clinically diagnosed cases of hepatitis was 38% and 32.4% by RPHA and ELISA respectively. In high risk individuals, the carrier rate was 14% by RPHA and 11% by ELISA. Taking ELISA as gold standard, RPHA showed 5.33% false positivity and 0.33% false negativity. The over all correlation between RPHA and ELISA was to the tune of 82.66%.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  590 68 -
Blood transfusion services : blood safety in India.
V H Talib, S K Khurana, S K Verma, S Ranga
October 1996, 39(4):255-6
Full text not available  [PDF]  [PubMed]
  426 70 -
Rationale and strategy for utilization of available blood in transfusion practice--an overview.
S K Khurana, A Thergaonkar, J S Dhupia, S K Verma, V H Talib
October 1996, 39(4):343-54
Full text not available  [PDF]  [PubMed]
  400 67 -
Xanthogranulomatous endometritis.
P B Badhe, B V Mittal, A P Desai
October 1996, 39(4):321-3
Full text not available  [PDF]  [PubMed]
  374 63 -
Verruciform xanthoma--a case report.
S Chandran, H Krishnaswami
October 1996, 39(4):307-8
Full text not available  [PDF]  [PubMed]
  364 71 -
Bilateral mammary metastasis of alveolar soft part sarcoma--a case report.
G A Muzumdar, A K Murthy
October 1996, 39(4):325-7
Full text not available  [PDF]  [PubMed]
  358 45 -
Tumoral calcinosis--a case report.
R Sagar, S Rammohan, R Mohan, V Sagar
October 1996, 39(4):309-10
Full text not available  [PDF]  [PubMed]
  362 32 -
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