Indian Journal of Pathology and Microbiology

: 2023  |  Volume : 66  |  Issue : 1  |  Page : 148--151

Epithelioid trophoblastic tumor: A case series

Subhashree Subhasmita Dash, Uma Sakhadeo, Srushti Karmarkar, Neha Mittal, Santosh Menon, Bharat Rekhi, Kedar Kamalakar Deodhar 
 Department of Pathology, Tata Memorial Centre, Mumbai, Maharashtra, India

Correspondence Address:
Kedar Kamalakar Deodhar
Department of Pathology, Annexe Building, 8thFloor, Tata Memorial Hospital, Dr. E Borges Road, Parel, Mumbai - 400 012, Maharashtra

An epithelioid trophoblastic tumor (ETT) is an extremely rare gestational trophoblastic tumor. Cases of ETT present with abnormal vaginal bleeding in women of reproductive age group with marginally elevated beta human chorionic gonadotrophin (B-hCG) levels. Here, we describe a series of four patients (all were females) including histomorphology, immunoprofiles, and diagnostic difficulty of this rare entity. All cases were in their reproductive age group. The mean pre-treatment hCG level was 665.24 (mIU/mL). Microscopically, all cases had a tumor showing an epithelioid appearance arranged in large nests and sheets. Individual tumor cells were round to polygonal with abundant eosinophilic cytoplasm, with central vesicular nuclei and prominent nucleoli. Areas of hemorrhage, necrosis, and intercellular hyaline-like material deposition were identified in all cases (100%). Immunohistochemically, tumor cells in all cases showed diffuse positivity for AE1/AE3 and p63 (100%). GATA3 was available in one case (25%), which was positive in the tumor cells. In one case (25%), hPL was focally positive, and in one case (25%), it was negative. SALL4 was performed in two cases (50%) and was negative in tumor cells. The mean Ki67 labeling index was 19.2 (range 10–30%). All four patients underwent surgical intervention and were treated with hysterectomy. The mean follow-up in this series was 39.4 months (range 6–70), and all patients are alive to date with a mean survival of 32.8 months (range, 4–67).

How to cite this article:
Dash SS, Sakhadeo U, Karmarkar S, Mittal N, Menon S, Rekhi B, Deodhar KK. Epithelioid trophoblastic tumor: A case series.Indian J Pathol Microbiol 2023;66:148-151

How to cite this URL:
Dash SS, Sakhadeo U, Karmarkar S, Mittal N, Menon S, Rekhi B, Deodhar KK. Epithelioid trophoblastic tumor: A case series. Indian J Pathol Microbiol [serial online] 2023 [cited 2023 Mar 21 ];66:148-151
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