Indian Journal of Pathology and Microbiology

ORIGINAL ARTICLE
Year
: 2022  |  Volume : 65  |  Issue : 4  |  Page : 755--760

Immunohistochemical evaluation of E-cadherin in oral epithelial dysplasia and squamous cell carcinoma


Jaishree Sharma1, Manish Bhargava1, Shivani Aggarwal1, Ashim Aggarwal2, Anchal Varshney1, Disha Chopra1 
1 Department of Oral Pathology and Microbiology, Manav Rachna Dental College, Faridabad, Haryana, India
2 Department of Oral and Maxillofacial Surgery, Manav Rachna Dental College, Faridabad, Haryana, India

Correspondence Address:
Jaishree Sharma
856, Dr. Mukherjee Nagar, Delhi - 110 009
India

Aim: To evaluate the expression of E-cadherin (E-cad) in oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). Material and Method: Immunohistochemistry was used to detect E-cad expression in 20 cases each of normal oral mucosa, oral epithelial dysplasia and squamous cell carcinoma. Statistical Analysis Used: Inferential statistical methods for statistical analysis used were Chi-square test for comparison of the frequency between different severity of dysplasia and OSCC. Results: Upon assessing the expression of E-cad in OED and OSCC, increase in E-cad immunoreactivity was seen in early lesions. However, the expression of E-cad decreased significantly as the grade of dysplasia increased. Conclusion: We observed a significant decrease in E-cad expression from dysplasia to poorly differentiated squamous cell carcinoma suggesting that loss of expression of E-cad is closely related to carcinoma.


How to cite this article:
Sharma J, Bhargava M, Aggarwal S, Aggarwal A, Varshney A, Chopra D. Immunohistochemical evaluation of E-cadherin in oral epithelial dysplasia and squamous cell carcinoma.Indian J Pathol Microbiol 2022;65:755-760


How to cite this URL:
Sharma J, Bhargava M, Aggarwal S, Aggarwal A, Varshney A, Chopra D. Immunohistochemical evaluation of E-cadherin in oral epithelial dysplasia and squamous cell carcinoma. Indian J Pathol Microbiol [serial online] 2022 [cited 2022 Nov 28 ];65:755-760
Available from: https://www.ijpmonline.org/article.asp?issn=0377-4929;year=2022;volume=65;issue=4;spage=755;epage=760;aulast=Sharma;type=0