Indian Journal of Pathology and Microbiology

CASE REPORT
Year
: 2022  |  Volume : 65  |  Issue : 3  |  Page : 705--708

Small cell variant anaplastic large cell lymphoma presenting as leukemia: A case report and review of Literature


Rimlee Dutta1, Prashant Ramteke1, Sandeep R Mathur1, Renu Saxena2, Hara prasad Pati2, Saumyaranjan Mallick1 
1 Department of Pathology, All India Institute of Medical Sciences, New Delhi, India
2 Department of Hematology, All India Institute of Medical Sciences, New Delhi, India

Correspondence Address:
Saumyaranjan Mallick
Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi - 110029
India

Anaplastic large cell lymphoma (ALCL) is a subcategory of the mature T-cell neoplasm characterized by sheets of cluster of differentiation (CD)30-positive pleomorphic large cells mostly present as lymphadenopathy. Here, we describe a case of Small cell variant ALCL with leukemic presentation without lymphadenopathy. A 68-year-old male presented with fatigue and weakness; examination revealed a total leukocyte count of 295,000/uL. The peripheral smear showed cells having cerebriform nuclei comprising 90% of the leukocytes. The flow cytometry showed that the cells were immunopositive for CD3 (weak), CD4, CD7, and negative for the rest of the markers. The cell blocks from the peripheral blood showed cells with immunopositivity for CD30, anaplastic lymphoma kinase (ALK), and Epithelial membrane antigen (EMA). A diagnosis of the small cell variant of ALK-positive ALCL was made. Due to the presence of atypical pleomorphic cells without lymphadenopathy, the case has a diagnostic dilemma with differential diagnosis of Sezary syndrome, T-cell prolymphocytic leukemia, and adult T-cell leukemia/lymphoma. Karyotyping and additional immunohistochemistry help for the confirmation of the diagnosis.


How to cite this article:
Dutta R, Ramteke P, Mathur SR, Saxena R, Pati Hp, Mallick S. Small cell variant anaplastic large cell lymphoma presenting as leukemia: A case report and review of Literature.Indian J Pathol Microbiol 2022;65:705-708


How to cite this URL:
Dutta R, Ramteke P, Mathur SR, Saxena R, Pati Hp, Mallick S. Small cell variant anaplastic large cell lymphoma presenting as leukemia: A case report and review of Literature. Indian J Pathol Microbiol [serial online] 2022 [cited 2022 Oct 5 ];65:705-708
Available from: https://www.ijpmonline.org/article.asp?issn=0377-4929;year=2022;volume=65;issue=3;spage=705;epage=708;aulast=Dutta;type=0