Indian Journal of Pathology and Microbiology

EDITORIAL
Year
: 2021  |  Volume : 64  |  Issue : 4  |  Page : 629--630

From Editor's desk


Ranjan Agrawal 
 MD; FIC Path; MIAC, DHA, Professor & Head, Department of Pathology, Rajshree Medical Research Institute, Bareilly, Uttar Pradesh, India

Correspondence Address:
Ranjan Agrawal
MD; FIC Path; MIAC, DHA, Professor & Head, Department of Pathology, Rajshree Medical Research Institute, Bareilly, Uttar Pradesh
India




How to cite this article:
Agrawal R. From Editor's desk.Indian J Pathol Microbiol 2021;64:629-630


How to cite this URL:
Agrawal R. From Editor's desk. Indian J Pathol Microbiol [serial online] 2021 [cited 2021 Nov 27 ];64:629-630
Available from: https://www.ijpmonline.org/text.asp?2021/64/4/629/328591


Full Text



Dear Readers!

Greetings from the Editorial office!

As we move ahead with the fifth issue of IJPM in 2021, memories stroll alongside. In July this year, we received the official mail stating an increase in the Impact factor of the journal. This provided a great boost to our morale. The working system of the journal has also changed attracting a good number of articles even by authors from abroad.

The present October–December 2021 issue has a pot pourri of interesting articles. Cases of rheumatic heart disease that are missed out in spite of stringent clinical criteria remain a great challenge for pathologists. Such cases that remain undiagnosed for a long duration or recur result in complications. It is at this crucial point in time that a correct interpretation by a pathologist comes in handy. Goyal et al. in their article have highlighted these facts.[1] Malignant mesothelioma carries with it a poor prognosis. Timely and accurate diagnosis requires a spectrum of immunohistochemical markers. Also, these markers help in differentiating between overlapping conditions.[2] As the name suggests – The ring and sling complex – including the congenital tracheal stenosis and left pulmonary artery abnormality result in narrowing of the lumen of the trachea. Surgical intervention results in a favorable prognosis, so again a timely diagnosis is mandatory.[3]

Carcinoma of the gall bladder is multifactorial as well as associated with multiple genetic alterations. Molecular diagnosis is helpful in early detection, response to treatment and plays a role in tumor progression. Immunohistochemical markers were used by authors for correlating these associations.[4] Similarly, periampullary carcinoma has different subtypes, each with a different prognosis. Murli Manohar et al. in their research have emphasized the role of various immunohistochemical markers including MUC1, CK 20, and CDX2 to diagnose specimens labeled as inconclusive or as mixed subtypes. Pancreaticobiliary subtype carries a poor prognosis. The authors emphasize that not a single marker, but a combination of these markers serve as better indicator in unidentified cases.[5]

Lesions of the synovium are an important cause of morbidity. Tevatia et al. in their article have stressed the role of a synovial biopsy in differentiating between different types of arthritis as well as in the early diagnosis of arthritis leading to safer therapeutic interventions.[6] Malignant lesions of the synovium are important differential in many clinical conditions. Reverse transcription-polymerase chain reaction (RT-PCR) or fluorescence in situ hybridization (FISH) is useful for the diagnosis as well as in the differentiation of these lesions. Immunohistochemical markers including TLE 1, INI1, ß-catenin, claudin 1, CK7, CK 19, SS 18, and calponin were used by Madakshira et al.[7] for the differentiation between various subtypes of synovial sarcoma as well as the close differentials.[7]

The deadly sting of COVID-19 is not over yet. Various markers indicating hematological, coagulation, and inflammatory changes in the body of those infected indicate the severity of the disease, resulting in the timely institution of treatment. This ensures low morbidity as well as mortality rates. Markers such as D-Dimer, lactate dehydrogenase (LDH), and C-reactive protein (CRP) have been found to carry important screening roles.[8] Much emphasis is laid nowadays on medical education. Ensuring a higher level of cognitive domain, including interpretation, analysis, and solution to problems that are clinically based, is important aspect of learning. Bhusnurmath et al. have stressed the various aspects of changes or requirements in the existing teaching methodology that will have a greater impact on the students and help them in better retention of their knowledge.[9]

I am sure that such good, multisectoral, and in-depth articles would attract a large number of readers, who would then be motivated further to write and contribute a greater number of research submissions. The final target is to take the Impact Factor to a much greater height. I sincerely once again take the opportunity of extending my thanks to the reviewers as well as members of the Editorial board who spared their valuable time in taking care of the articles at all stages. There are many notices published in this issue. I request all the readers to carefully go through them.

Jai Hind!

References

1Goyal A, Vaideeswar P, Daga P, Bhargav R. Acute rheumatic fever – A pathological analysis of clinically missed cases. Indian J Pathol Microbiol 2021;64:651-4.
2Patel T, Aswal P. Malignant mesothelioma: A clinicopathological study of 76 cases with emphasis on immunohistochemical evaluation along with review of literature. Indian J Pathol Microbiol 2021;64:655-63.
3Ray M, Sathe P, Vaideeswar P, Marathe SP. The ring-and-sling complex – Does it “Ring” true? Indian J Pathol Microbiol 2021;64: 683-86.
4Singh P, Jain SL, Sakhuja P, Agarwal A. Expression of VEGF-A, HER2 NEU and KRAS in gall bladder carcinoma and their correlation with clinico-pathological parameters. Indian J Pathol Microbiol 2021;64; 687-92.
5Murli Manohar K, Sasikala M, Anuradha S, Ramji C, Sashidhar RB, Rao GV, et al. MUC1, CK20 and CDX2 immunohistochemical markers can sub-classify periampullary carcinomas into pancreaticobiliary, intestinal, and mixed subtypes. Indian J Pathol Microbiol 2021;64: 693-701.
6Tevatia MS, Goyal N, Baranwal AK, Mishra PS, Gupta A, Sharma V, et al. A study to analyze the pattern of synovial lesions from synovial biopsies in a tertiary care centre. Indian J Pathol Microbiol 2021;64:702-6.
7Madakshira MG, Radotra BD, Kaman L, Saikia UN. Expression of TLE1, INI1, β-catenin, Claudin1, CK7, CK19, SS18 and calponin in synovial sarcoma. Indian J Pathol Microbiol 2021;64:707-16.
8Lokwani DP, Yadav BS, Bharti S, Gupta V, Toppo N. Evaluation of hematological, coagulation and inflammatory biomarker's role in predicting the severity of disease in COVID-19 patients, admitted in designated COVID-19 hospital of central India. Indian J Pathol Microbiol 2021;64:735-40.
9Bhusnurmath SR, Bhusnurmath BS, Goyal SR. Helping medical students to learn pathology more effectively. Indian J Pathol Microbiol 2021;64: 746-51.