Indian Journal of Pathology and Microbiology

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 64  |  Issue : 1  |  Page : 65--68

Serum CA 19-9 and CA 125 as a diagnostic marker in carcinoma of gallbladder


Manoj K Bind, Ravi R Mishra, Varsha Kumar, Vatsala Misra, Premala A Singh 
 Department of Pathology, Motilal Nehru Medical College, Allalhabad, Uttar Pradesh, India

Correspondence Address:
Varsha Kumar
Deparment of Pathology, M.L.N.Medical College, Allahabad - 211 002, Uttar Pradesh
India

Background: Gall bladder carcinoma is endemic in North India along the Ganges belt. Most of the cases usually present in late stage when prognosis is poor. That mandates a necessity for proper screening in these areas for gall bladder lesions. Tumor markers CA 19-9 and CA 125 have been studied in various GI cancers and may also help in the screening, diagnosis and evaluation of gall bladder carcinoma. Aims: To assess serum CA19-9 and serum CA125 in patients with gall bladder lesions and find out a cut off value for diagnosis of carcinoma gallbladder. Methods and Material: Study included 118 cases, with female: male ratio of 4:1.Out of it, 91 (77 %) cases were benign and 27 (23 %) were malignant. Patients' sera was collected and analyzed for CA19-9 and CA 125 by CMIA method. Results: The Mean (SD) value of CA19-9 for benign and malignant cases was found to be 12.86 (17.54) and 625.35(186.52) U/ml. For CA 125 it was found to be 17.98(13.69) and 239.63(73.72) U/ml respectively. The difference was statistically significant (P< 0.001). When Mean - 2SD value of malignant lesions were taken as cut off a value of CA 19-9 and CA 125 were found be 252.31 U/ml & 92.19U/ml respectively, found to be significant to suggest /diagnose a case of carcinoma gall bladder along with clinicoradiological findings. Taking these value as cut off Sensitivity & Specificity for CA 19-9 and CA 125 in detecting malignant cases were found to be 100% & 98.90% and 100% & 94.50% respectively. Conclusions: It is concluded that both serum CA 19-9 and serum CA 125 may act as a good adjunct for diagnosis of cases of carcinoma gallbladder along with imaging studies. However, changes in CA19-9 are more significant than CA 125.


How to cite this article:
Bind MK, Mishra RR, Kumar V, Misra V, Singh PA. Serum CA 19-9 and CA 125 as a diagnostic marker in carcinoma of gallbladder.Indian J Pathol Microbiol 2021;64:65-68


How to cite this URL:
Bind MK, Mishra RR, Kumar V, Misra V, Singh PA. Serum CA 19-9 and CA 125 as a diagnostic marker in carcinoma of gallbladder. Indian J Pathol Microbiol [serial online] 2021 [cited 2022 May 26 ];64:65-68
Available from: https://www.ijpmonline.org/article.asp?issn=0377-4929;year=2021;volume=64;issue=1;spage=65;epage=68;aulast=Bind;type=0