Indian Journal of Pathology and Microbiology

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 63  |  Issue : 5  |  Page : 30--33

Immunoexpression of estrogen receptor-β and progesterone receptor in prostate adenocarcinoma, does it inhibit neoplastic proliferation and invasion?


Kinjal N Bera1, Shakti K Yadav1, Om Prakash2, Sompal Singh1, Namrata Sarin1 
1 Department of Pathology, North Delhi Municipal Corporation Medical College and Hindu Rao Hospital, Delhi, India
2 Department of Urology, North Delhi Municipal Corporation Medical College and Hindu Rao Hospital, Delhi, India

Correspondence Address:
Namrata Sarin
Department of Pathology, North Delhi Municipal Corporation Medical College and Hindu Rao Hospital, Delhi
India

Context: The roles of estrogen and progesterone in human prostate carcinogenesis have been only recently recognized. Aims: This study was conducted to evaluate the expressions of esterone receptor-beta (ER-β), progesterone receptor (PR), and Ki-67 in benign and malignant lesions of the prostate. Settings and Design: The study was conducted at a tertiary care hospital. It was an analytical cross-sectional study. Materials and Methods: We selected a total of 39 cases including 26 cases of benign prostatic hyperplasia and 13 cases of adenocarcinoma prostate. The proportion of cases showing expression for ER-β, PR, and Ki-67 was noted for both groups. A difference in immunoexpression between benign and malignant cases was evaluated. Association between receptor expression and Gleason grade was evaluated for malignant cases. Statistical Analysis Used: To compare the difference in expressions of ER-β, PR, and Ki-67 Mann–Whitney U test was used. Association between ER-β, PR, and Ki-67 expression and Gleason grade was analyzed using the Chi-square test. Results: ER-β expression was seen in all benign and malignant cases, whereas the majority of the malignant cases (61.54%) were negative for progesterone expression. Epithelial expressions of ER-β and PR were significantly higher in benign as compared with malignant lesions. Malignant cases showed a significantly higher expression of Ki-67. However, we did not find any association between the expressions of these markers with Gleason grade. Conclusions: The expressions of ER-β and PR were significantly higher in the epithelium in benign cases as compared with malignant cases. Ki-67 expression was significantly higher in the malignant group as compared with the benign group.


How to cite this article:
Bera KN, Yadav SK, Prakash O, Singh S, Sarin N. Immunoexpression of estrogen receptor-β and progesterone receptor in prostate adenocarcinoma, does it inhibit neoplastic proliferation and invasion?.Indian J Pathol Microbiol 2020;63:30-33


How to cite this URL:
Bera KN, Yadav SK, Prakash O, Singh S, Sarin N. Immunoexpression of estrogen receptor-β and progesterone receptor in prostate adenocarcinoma, does it inhibit neoplastic proliferation and invasion?. Indian J Pathol Microbiol [serial online] 2020 [cited 2022 May 27 ];63:30-33
Available from: https://www.ijpmonline.org/article.asp?issn=0377-4929;year=2020;volume=63;issue=5;spage=30;epage=33;aulast=Bera;type=0