Indian Journal of Pathology and Microbiology

REVIEW ARTICLE
Year
: 2012  |  Volume : 55  |  Issue : 2  |  Page : 147--153

Review of stem cell deregulation and breast cancer: An emerging hypothesis


Darnal Hari Kumar1, Methil Kannan Kutty2 
1 Pathology, Monash University Sunway campus, Johor Bahru, Malaysia
2 Pathology, Faculty of Medicine and Health Sciences, Universiti Sains Islam Malaysia, Kuala Lumpur, Malaysia

Correspondence Address:
Methil Kannan Kutty
Pathology, Faculty of Medicine and Health Sciences, Universiti Sains Islam Malaysia, Kuala Lumpur
Malaysia

Cancer is fundamentally a cellular genetic disease capable of transferring the DQdiseaseDQ to the next generation of mutated cells. Similar proliferative and information transferring capacity exists in the stem cells of various organ systems in the human body. Understanding the bio-mechanism of stem cell metabolism and its regulation by signaling molecules and extracellular micro-environment is an important step toward successful prevention and treatment of cancer. According to the cancer stem cell hypothesis, both hereditary and sporadic cancers can arise from deregulation of these cancer stem cells (CSCs), triggered by genetic and environmental factors. It is shown that deregulation of normal self-renewal pathways in undifferentiated breast stem cells or progenitor cells had altered mammary system or progenitor cells, resulting in abnormally differentiated cells in human and rodent breast cancer cell lines. Breakthroughs in molecular pathways have important therapeutic implications. Hence, significant stress is laid on targeting signaling molecules and their micromilieu in breast cancer therapy.


How to cite this article:
Kumar DH, Kutty MK. Review of stem cell deregulation and breast cancer: An emerging hypothesis.Indian J Pathol Microbiol 2012;55:147-153


How to cite this URL:
Kumar DH, Kutty MK. Review of stem cell deregulation and breast cancer: An emerging hypothesis. Indian J Pathol Microbiol [serial online] 2012 [cited 2022 Aug 12 ];55:147-153
Available from: https://www.ijpmonline.org/article.asp?issn=0377-4929;year=2012;volume=55;issue=2;spage=147;epage=153;aulast=Kumar;type=0