Indian Journal of Pathology and Microbiology


Year
: 2007  |  Volume : 50  |  Issue : 3  |  Page : 640--3

Role of bone marrow trephine biopsy in the diagnosis of marrow involvement in Hodgkin俟Q製 disease.


R Subramanian, D Basu, B Badhe, Tarun K Dutta 
 Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry

Correspondence Address:
R Subramanian
Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry

Bone marrow involvement in Hodgkin俟Q製 disease alters the stage and hence the prognosis and treatment modality. Seventy-six patients of biopsy proven Hodgkin俟Q製 disease in whom a bone marrow aspiration and biopsy were done simultaneously at the time of diagnosis were included in the study. Bone marrow involvement was seen in 14 (18%) cases. All 14 cases were diagnosed on biopsy. Only one aspirate was suspicious of involvement. Rest was either diluted (28%) or was normal (64%). Eleven patients were upstaged from stage I, II and III to stage IV. All patients had cytopenia of one or more cell line. Increased fibrosis, necrosis and a polymorphic cellular infiltrate were associated findings in the marrow. We wish to highlight the importance of bone marrow trephine biopsy over aspirate in staging even clinically early stage Hodgkin俟Q製 disease.


How to cite this article:
Subramanian R, Basu D, Badhe B, Dutta TK. Role of bone marrow trephine biopsy in the diagnosis of marrow involvement in Hodgkin's disease. Indian J Pathol Microbiol 2007;50:640-3


How to cite this URL:
Subramanian R, Basu D, Badhe B, Dutta TK. Role of bone marrow trephine biopsy in the diagnosis of marrow involvement in Hodgkin's disease. Indian J Pathol Microbiol [serial online] 2007 [cited 2023 Feb 8 ];50:640-3
Available from: https://www.ijpmonline.org/article.asp?issn=0377-4929;year=2007;volume=50;issue=3;spage=640;epage=3;aulast=Subramanian;type=0