Year : 1998 | Volume
: 41 | Issue : 4 | Page : 423--6
A simple screening test for the detection of heterozygous beta thalassemia.
A A Thool, M S Walde, A V Shrikhande, V H Talib
Department of Laboratory Medicine, Safdarjung Hospital, New Delhi
Correspondence Address:
A A Thool
Department of Laboratory Medicine, Safdarjung Hospital, New Delhi
Beta-Thalassemia is prevalent in a high frequency of 5-15% in selected geographical areas and ethnic communities. There is need to screen large populations for the heterozygotes of beta-Thalassemia. We have evaluated NESTROFT (Naked eye single tube red cell osmotic fragility test) with 0.36% buffered saline in this study. Of the population screened, 42 cases were positive with NESTROFT, of which 40 were positive with the confirmatory test for beta-Thalassemia. This implies a positive predictive value and specificity of 100%, negative predictive value of 83.3% and sensitivity of 95.2%.
How to cite this article:
Thool A, Walde M, Shrikhande A, Talib V. A simple screening test for the detection of heterozygous beta thalassemia. Indian J Pathol Microbiol 1998;41:423-6
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How to cite this URL:
Thool A, Walde M, Shrikhande A, Talib V. A simple screening test for the detection of heterozygous beta thalassemia. Indian J Pathol Microbiol [serial online] 1998 [cited 2023 Jun 3 ];41:423-6
Available from: https://www.ijpmonline.org/article.asp?issn=0377-4929;year=1998;volume=41;issue=4;spage=423;epage=6;aulast=Thool;type=0 |
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