Indian Journal of Pathology and Microbiology
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Plasmablastic transformation of a double hit follicular lymphoma: An emerging entity

1 Department of Laboratory Medicine, P.D. Hinduja Hospital and Medical Research Centre, Mumbai, Maharashtra, India
2 Department of Cancer and Clinical Genetics, Lilac Insights Private Limited, Mumbai, Maharashtra, India

Correspondence Address:
Vidisha Mahajan,
S-1 building, P. D. Hinduja Hospital and Medical Research Centre, Mahim, Mumbai - 400 016, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijpm.ijpm_898_21

Plasmablastic transformation of follicular lymphoma is very rare and has been reported in only 5 cases till date. We report a case of simultaneous identification of extranodal, soft tissue plasmablastic lymphoma in the ankle and bone marrow involvement by follicular lymphoma. This unusual case presentation is a challenge for the treating physician with the patient becoming resistant to chemotherapy and succumbing to the disease within a few months of diagnosis. These cases are known to have an aggressive clinical course with very poor prognosis and survival rate of less than 6 months. This report broadens the spectrum of morphological transformation of follicular lymphoma and it may represent a new category of high-grade transformation of follicular lymphoma.

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