Indian Journal of Pathology and Microbiology
Home About us Instructions Submission Subscribe Advertise Contact e-Alerts Ahead Of Print Login 
Users Online: 9021
Print this page  Email this page Bookmark this page Small font sizeDefault font sizeIncrease font size
 
ORIGINAL ARTICLE
Ahead of Print

Secondary infections in COVID-19: Antemortem and Postmortem culture study


1 Department of Microbiology, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi, India
2 PhD Scholar, Division of Forensic Pathology and Molecular DNA, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi, India
3 Division of Clinical Microbiology, Department of Laboratory Medicine, JPNATC, All India Institute of Medical Sciences, New Delhi, India
4 Department of Anaesthesia and Critical Care, All India Institute of Medical Sciences, New Delhi, India
5 Department of Orthopedics, All India Institute of Medical Sciences, New Delhi, India
6 Division of Forensic Pathology and Molecular DNA, JPNATC, AIIMS, New Delhi, India

Correspondence Address:
Purva Mathur,
Division of Clinical Microbiology, Department of Laboratory Medicine, JPNATC, AIIMS, New Delhi- 110 029
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijpm.ijpm_141_22

Background: Secondary bacterial infections during COVID-19 hospitalization have been reported in about 6–15% of patients. Aims: To study the secondary bacterial infections that affected the COVID-19 patients during their hospitalisation and to unearth the bacteriological profile of samples obtained after their demise. Settings and Design: This prospective study was carried out at a COVID-19 dedicated, apex tertiary care centre in North India from July 2020 to April 2021. Methods and Material: Samples of 268 patients were considered for the study. Nasopharyngeal swab specimen, blood, and tissue (lung) were collected from the deceased body as early as possible and processed. Statistical Analysis: Statistical analyses were performed using STATA version 11.1 (Stata Corp., College Station, TX, USA). Results: A total of 170 samples were received from patients before their death, which included blood, urine, respiratory samples, pus, and cerebrospinal fluid. Forty-four pathogens were isolated, which consisted of Acinetobacter baumannii (43.1%), Klebsiella pneumoniae (36.3%), Escherichia coli (11.3%), and Pseudomonas aeruginosa (4.5%), Enterococcus faecium (4.5%). Two hundred fifty-eight samples were collected from the deceased bodies wherein the nasopharyngeal sample was highest, followed by tissue and blood. A total of 43 pathogens were isolated among them which included A. baumannii (44.1%), followed by K. pneumoniae (25.5%), E. coli (20.9%), P. aeruginosa (6.97%) and Enterobacter cloacae (2.3%). All these isolates were highly resistant to antimicrobials. Conclusions: In our study, bacterial profiles in antemortem and postmortem samples were found to be similar, suggesting that resistant pathogens may be the cause of mortality in COVID-19 infected hospitalised patients.


Print this article
Search
 Back
 
  Search Pubmed for
 
    -  Kiro VV
    -  Sharma M
    -  Srivastava S
    -  Lalwani P
    -  Aggarwal R
    -  Soni KD
    -  Malhotra R
    -  Lalwani S
    -  Mathur P
    -  Trikha A
 Citation Manager
 Article Access Statistics
 Reader Comments
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed225    
    PDF Downloaded12    

Recommend this journal