Indian Journal of Pathology and Microbiology
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The expression of squalene epoxidase in human gastric cancer and its clinical significance

1 Department of Basic Medicine, Luohe Medical College; Tumor Occurrence and Prevention Research Innovation Team of Henan, Luohe, Henan, PR China
2 Department of Pharmacology, Luohe Medical College; Tumor Occurrence and Prevention Research Innovation Team of Henan, Luohe, Henan, PR Chinax
3 Department of Pathology, Taicang Affiliated Hospital of Soochow University; Department of Pathology, The First People's Hospital of Taicang, Taicang, Jiangsu, PR China
4 Department of Basic Medicine, Luohe Medical College, Luohe, Henan, PR China
5 Tumor Occurrence and Prevention Research Innovation Team of Henan; Clinical, Luohe Medical College; Henan Province Engineering and Technology Research center of Foods for Special Medical Purpose, Luohe, Henan, PR China

Correspondence Address:
Guo-Jian Gu,
Department of Pathology, Taicang Affiliated Hospital of Soochow University, 58 South Changsheng Road, Taicang 215400, Jiangsu
PR China
Song-Tao Xu,
Department of Clinical, Luohe Medical College, 148 Daxue Road, Luohe 462002, Henan
PR China
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijpm.ijpm_1183_21

Context: Squalene epoxidase (SQLE) is overexpressed in a variety of tumors, which may play an important role in their tumorigenesis, development, and prognosis. Aims: The aim of this study is to investigate the expression of SQLE and explore its clinicopathological significance in gastric cancer. Settings and Design: The correlation between its positive expression and the pathological characteristics of patients (such as sex, age, tumor size, survival, tumor differentiation, TNM staging, and lymph node metastasis) was analyzed. Methods and Material: Immunohistochemical method was used to detect its expression in 107 cases of gastric carcinoma and 34 cases of tumor-adjacent tissues. Statistical Analysis Used: Counting data were analyzed by Chi-square test. Its overall survival was analyzed by Kaplan-Meier method and log-rank test. Its hazard factors were analyzed by Cox multivariate analysis. Results: The positive rate of SQLE in gastric cancer is 67.3%, which is higher than that in tumor-adjacent tissues (17.6%), <0.001. Expression of SQLE is closely related to tumor differentiation, TNM staging and lymph node metastasis (P = 0.030, P = 0.009, and P = 0.011, respectively). Furthermore, compared with those low expression of SQLE, the patients of overexpression had worse overall survival by Kaplan–Meier analysis (P = 0.025). Cox multivariate analysis shows that lymph node metastasis, tumor differentiation, SQLE, and TNM staging are independent factors for prognosis of gastric cancer (P = 0.003, 0.020, 0.018, and P = 0.001 respectively). Conclusions: SQLE is overexpressed in gastric cancer. It could be used for the diagnosis and prognosis of the gastric cancer patients.

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