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Role of Orthopedia Homebox Protein in Subclassification of Pulmonary Carcinoid Tumors: Retrospective Analysis of 110 Cases
Mehmet Çetin1, Göktürk Fındık2, Funda Demirağ3, İlteriş Türk2, Koray Aydoğdu2
1 Department of Thoracic Surgery, Omer Halisdemir University Training and Research Hospital, Niğde, Turkey
2 Department of Thoracic Surgery, Ataturk Chest Disease and Thoracic Surgery Training and Research Hospital, Ankara, Turkey
3 Department of Pathology, Ataturk Chest Disease and Thoracic Surgery, Training and Research Hospital, Ankara, Turkey
Correspondence Address:
Mehmet Çetin,
MD, Department of Thoracic Surgery, Omer Halisdemir University Training and Research Hospital, Niğde
Turkey
 Source of Support: None, Conflict of Interest: None DOI: 10.4103/ijpm.ijpm_210_22
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Background: Orthopedia homeobox protein (OTP), highlighted as a sensitive and specific marker for pulmonary carcinoids, may provide a more objective criterion for subclassification. Methods: A total of 110 patients who underwent surgery for pulmonary carcinoids (2009–2019) were included. Gender, age, application complaint, tumor diameter and location, typical and atypical tumor type, lymph node involvement, stage, recurrence, and survival data were evaluated retrospectively with OTP nuclear staining. Results: The sensitivity of OTP was 66.4%. OTP in subclassifying pulmonary carcinoids was not significant. There was no significant relationship between OTP and lymph node involvement, recurrence, and survival. Conclusion: OTP does not provide significant results in the subclassification of typical and atypical carcinoid tumors and the evaluation of recurrence and survival of carcinoid tumor cases.
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