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Prognostic value of serum cystatin C in patients with sepsis
Chunfang Hu1, Zhiyuan Zhang2, Bin Hou1, Han Xue1, Xuehua Pu1, Jilu Ye1
1 Department of Critical Care Medicine, Taizhou People's Hospital, Taizhou, Jiangsu, China
2 Department of Cardiovascular Medicine, Taizhou People's Hospital, Taizhou, Jiangsu, China
Correspondence Address:
Jilu Ye,
Department of Critical Care Medicine, Taizhou People's Hospital, Taizhou, Jiangsu
China
 Source of Support: None, Conflict of Interest: None DOI: 10.4103/ijpm.ijpm_804_21
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Background: Early identification and diagnosis of sepsis are very important because timely and appropriate treatment can improve the survival outcomes. Aim: The aim of this study was to explore the clinical significance of serum cystatin C level in sepsis. Methods: The levels of serum cystatin C, C-reactive protein (CRP), and procalcitonin (PCT) were measured via enzyme-linked immunosorbent assay (ELISA). The patients with sepsis were followed up for 30 days to record their survival conditions. Results: The expression level of cystatin C was remarkably elevated in patients with sepsis compared with that in healthy controls. The serum cystatin C level was significantly correlated with the SOFA score and CRP, PCT, and creatinine levels in patients with sepsis. The patients in death group had a markedly higher level of serum cystatin C than those in survival group. The area under curve (AUC) of cystatin C for assessing the 30-day mortality rate of sepsis patients was 0.765. Conclusion: The serum cystatin C level is elevated in patients with sepsis and it may serve as a biomarker for early diagnosis of sepsis and possess promising effects in assessing the severity of sepsis and the prognosis of patients.
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