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The rhabdoid variant of adrenocortical carcinoma---Report of three cases and literature review
Pavithra Ayyanar1, Mukund N Sable1, Amit K Adhya1, Manoj K Das2, Madhabananda Kar3, Pritinanda Mishra1
1 Department of Pathology and Lab Medicine, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, Odisha, India
2 Department of Urology, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, Odisha, India
3 Department of Surgical Oncology, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, Odisha, India
Correspondence Address:
Pritinanda Mishra,
Department of Pathology and Lab Medicine, All India Institute of Medical Sciences (AIIMS), Bhubaneswar - 751 019, Odisha
India
 Source of Support: None, Conflict of Interest: None DOI: 10.4103/ijpm.ijpm_515_21
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Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy. Extensive rhabdoid morphology in ACC has been described recently in very few cases. The proportion of rhabdoid morphology and the role of SMARCB1/ INI1 expression in these tumor cells to diagnose the specific variant is not described in the literature. We reviewed the clinicopathological features of nine cases of adrenocortical neoplasm. Out of which, three cases of ACC showed predominant rhabdoid morphology. Large discohesive cells with abundant cytoplasm containing eosinophilic inclusions, eccentric vesicular nucleus, and prominent nucleoli. INI1 immunostain was retained in all cases. We reported the rhabdoid variant of ACC, a novel entity, and its diagnostic approach from their histological mimickers. Identifying more cases of this entity will help to clearly understand the pathogenesis, biologic behaviour, and any specific molecular alterations in the future.
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