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Two case reports of mixed epithelial and stromal renal tumor of kidney in children and literature review analysis
Xia Wei1, Yizhen Wang1, Yuan Fang1, Lian Chen2
1 Department of Pathology, Anhui Provincial Children's Hospital, Hefei, China
2 Department of Pathology, Children's Hospital of Fudan University, Shanghai, China
Correspondence Address:
Lian Chen,
Department of Pathology, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai - 201102
China
 Source of Support: None, Conflict of Interest: None DOI: 10.4103/ijpm.ijpm_148_22
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Mixed epithelial and stromal tumor of the kidney (MESTK) occurs almost exclusively in perimenopausal women while rarely in children. Only five pediatric patients have been described previously. Herein, we report a girl and a boy with MESTK, aged 3- and 4-years-old, respectively. The two patients presented with hematuria or an abdominal mass. Histologically, the tumors were both composed of epithelial and stromal elements. Immunohistochemical staining of tumor cells expressed epithelial and mesenchymal component markers. They were diagnosed with MESTK by histology and immunohistochemistry after surgery. The patients were at good condition after surgery. To our knowledge, these are the youngest reported cases of MESTK. And the glandular luminal structure formed by the epithelium was lined with urothelium, which expanded the histological map of MESTK.
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