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Changes of lymphocyte subsets in smear-negative pulmonary tuberculosis
Xue Yang1, Hao Feng2
1 Infectious Diseases Section, Nanjing Jiangbei Hospital, Nanjing, China
2 Infectious Diseases Section, Nanjing Jiangbei Hospital; Infectious Diseases Section, Nanjing Pukou Central Hospital, Pukou Branch Hospital of Jiangsu Province Hospital, Nanjing, China
Correspondence Address:
Hao Feng,
Infectious Diseases Section, Nanjing Pukou Central Hospital, Pukou Branch Hospital of Jiangsu Province Hospital, Nanjing 211800
China
 Source of Support: None, Conflict of Interest: None DOI: 10.4103/ijpm.ijpm_72_21
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Background and Aims: The host immune system plays an important role in the pathogenesis and defense mechanism of Mycobacterium tuberculosis (Mtb). This study aimed to explore the different changes in the immune system between smear-negative pulmonary tuberculosis (PTB) and smear-positive PTB patients. Methods: A total of 85 active PTB patients and 50 healthy adults were enrolled. The participants were divided into smear-negative PTB, smear-positive PTB, and control groups. Chest computed tomography (CT) and lymphocyte subgroup counts in peripheral blood were measured in all participants. Results: There were higher numbers of CD4 + T-cells, NK cells, and pulmonary cavities in the smear-positive PTB group, whereas the numbers of B-ells were significantly increased in the smear-negative PTB group. Conclusions: Smear-negative PTB showed fewer pulmonary cavities, mild inflammatory response, lower numbers of immune cells, and higher numbers of B- cells.
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