Indian Journal of Pathology and Microbiology
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Primary orbital yolk sac tumor in an infant: A rare entity


1 Department of PediatricHematology and Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India
2 Department of Pathology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India

Correspondence Address:
Gauri Kapoor,
Department of Pediatric Hematology and Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector 5, Rohini, Delhi - 110085
India
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/IJPM.IJPM_741_21

We report a case of pure orbital yolk sac tumor (YST) in an 11-month-old infant, which is a rare entity. The child presented with progressive painless swelling of the right eye and on examination had proptosis, chemosis, and lid edema. Systemic examination was within normal limits. Magnetic resonance imaging (MRI) orbit revealed a lobulated heterogeneously enhancing right retroocular mass extending up to the orbital apex, displacing the optic nerve and eroding the medial orbital wall. Biopsy of the lesion revealed pure YST histology. Serum alpha-fetoprotein (AFP) was markedly raised at 76900 ng/mL. She was started on infant bleomycin etoposide cisplatin (BEP) chemotherapy protocol. There was a good clinical and radiological response. A high index of malignancy is required in young children presenting with orbital proptosis. A multidisciplinary approach and early intervention are essential to save both vision and life.


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    -  Mishra V
    -  Jain S
    -  Malhotra P
    -  Durga G
    -  Kapoor G
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