Indian Journal of Pathology and Microbiology
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CASE REPORT
Year : 2023  |  Volume : 66  |  Issue : 1  |  Page : 168-170

Clinician's dilemma: Naproxen-induced liver injury


1 Department of Pediatric Gastroenterology Cell, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India
2 Department of Pediatrics, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India
3 Department of Radiology, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India
4 Department of Paediatric Rheumatology, Dr Rajendra Prasad Government Medical College, Tanda, Kangra, Himachal Pradesh, India
5 Department of Pathology, SRL Ltd., Fortis Escorts, Okhla, New Delhi, India

Correspondence Address:
Shruti Sharma
Paediatric Gastroenterology Cell, Indira Gandhi Medical College, Shimla, Himachal Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijpm.ijpm_766_21

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Naproxen is a widely used nonsteroidal anti-inflammatory drug (NSAID) in pediatric population, used for mild-to-moderate pains, arthritis, and other immune-mediated disorders. It rarely causes clinically apparent liver injury in the adult population taking high doses of the drug over a prolonged period and is reported even rarer in pediatric population. We present a case of drug-induced liver injury (DILI) in a 13-year-old girl taking naproxen in therapeutic doses for juvenile rheumatoid arthritis. There was a complete recovery of liver function following discontinuation of naproxen therapy.


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