Indian Journal of Pathology and Microbiology
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Year : 2022  |  Volume : 65  |  Issue : 4  |  Page : 898-901

Three shades of black - secondary thrombotic microangiopathy


1 Department of Pathology, IPGME&R and SSKM Hospital, Kolkata, West Bengal, India
2 Nephrology, IPGME&R and SSKM Hospital, Kolkata, West Bengal, India

Correspondence Address:
Moumita Sengupta
244 AJC Bose Road, Kolkata- 700 020, West Bengal
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijpm.ijpm_1237_21

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Thrombotic microangiopathy is a group of disorders characterized by microangiopathic hemolytic anemia, thrombocytopenia and organ damage. Wide age distribution and the heterogeneity in presentation demand a deeper understanding into the pathogenesis of TMA. Primary TMA is distinct from TMA associated with secondary causes and remains clinically occult till a precipitating factor aggravates it. The extent and severity of renal damage caused by each of them is also distinct. The first alerting signal could be the presence of schistiocytes on peripheral smear and arteriolar thrombi on light microscopy. Thus in secondary TMA, identification of the underlying disorder is indispensible for targeted management.


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