Indian Journal of Pathology and Microbiology
Home About us Instructions Submission Subscribe Advertise Contact e-Alerts Ahead Of Print Login 
Users Online: 6427
Print this page  Email this page Bookmark this page Small font sizeDefault font sizeIncrease font size
ORIGINAL ARTICLE
Year : 2022  |  Volume : 65  |  Issue : 4  |  Page : 856-859

Significance of CD47 expression in endometrial carcinoma


1 Department of Pathology, Bezmialem Vakif University, Faculty of Medicine, Istanbul, Turkey
2 Department of Pathology, Yedikule Chest Hospital, Istanbul, Turkey
3 Department of Pathology, Biruni University, Faculty of Medicine, Istanbul, Turkey
4 Department of Obstetric and Gynecology, Bezmialem Vakif University, Faculty of Medicine, Istanbul, Turkey
5 Department of Biostatistics and Medical Informatics, Bezmialem Vakif University, Faculty of Medicine; Department of Biostatistics Bursa Uludag, University Institute of Health Sciences, Bursa, Turkey

Correspondence Address:
Nurhan Sahin
Adnan Menderes Boulevard P.C. 34093 Fatih, Istanbul
Turkey
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijpm.ijpm_223_21

Rights and Permissions

Objectives: CD47 is a membrane protein that belongs to the immunoglobulin superfamily and regulates macrophage phagocytosis negatively. As CD47 expression at the cancer cell membrane would inhibit the phagocytic activity of immune cells, it is connected to an unfavorable prognosis in leukemia and malignancies of various solid organs. Materials and Methods: In this study, retrospectively evaluated 72 patients who had been diagnosed with endometrial carcinoma at Pathology Department and had undergone total abdominal hysterectomy and bilateral salpingo-oophorectomy (TAH + BSO) and/or lymphadenectomy. CD47 expression was evaluated in tumorous and nontumor areas in all patients considering cytoplasmic and membranous brown staining in cells. The proportion of expression was evaluated as well as the intensity and an “h score” was obtained. This score was compared with known prognostic parameters. Results: CD47 expressions showed a statistically significant correlation with tumor grade (P < 0.05); however, no significant relationship was observed with myometrial invasion depth and lymph vascular invasion status (P = 0.923 and P = 0.754, respectively). Conclusions: As with other tumors, anti-CD47 antibody may be an alternative treatment option in patients with high-grade endometrial carcinoma.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed300    
    Printed17    
    Emailed0    
    PDF Downloaded18    
    Comments [Add]    

Recommend this journal