Indian Journal of Pathology and Microbiology
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Year : 2022  |  Volume : 65  |  Issue : 4  |  Page : 851-855

Tumor budding is a valuable prognostic parameter in endometrial carcinomas

Department of Pathology, Ataturk Training and Research Hospital, Izmir Katip Celebi University, Izmir, Turkey

Correspondence Address:
Irfan Ocal
Atatürk Training and Research Hospital, Gazeteci Hasan Tahsin Street, Basinsitesi, Postal Code: 35360, Izmir
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijpm.ijpm_109_21

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Background: Tumor budding (TB) is a morphological finding believed to play an important role in determining the prognosis in many cancers. Aim: Our aim is to evaluate the prognostic importance of TB in endometrial carcinomas. Settings and Design: Two-hundred-eleven endometrial cancers were obtained from 2008 to 2015 that were comprised of those having undergone surgical staging with a hysterectomy and at least 5 years followed up. Material and Methods: All hematoxylin and eosin stained slides were reevaluated for the status of TB. Statistical Analysis: Nonparametric tests, the Kaplan–Meier method, the Log-rank test, and Cox proportional hazard regression were used. Results and Conclusion: TB was found to correlated with larger diameter (P = 0.000), nonendometrioid (P = 0.038), mixed cell types (P = 0.005), higher grade (P = 0.000), deeper invasion of the myometrium (P = 0.000), cervical stromal invasion (P = 0.000), advanced pT (P = 0.011), lymph node involvement (P = 0.000), lymphovascular invasion (P = 0.000), and advanced stage (P = 0.000). The presence of TB worsens the 5-year overall survival (OS) (P = 0.0001). In cases such as grade 1, pT1, or stage 1 endometrial carcinomas, the presence of TB decreases the OS rate (P = 0.00017, P = 0.0016, P < 0.0001). Our result suggested that the presence of TB adversely affects the prognosis. It was concluded that TB could be a valuable prognostic parameter.

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