Indian Journal of Pathology and Microbiology
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Year : 2022  |  Volume : 65  |  Issue : 4  |  Page : 755-760

Immunohistochemical evaluation of E-cadherin in oral epithelial dysplasia and squamous cell carcinoma

1 Department of Oral Pathology and Microbiology, Manav Rachna Dental College, Faridabad, Haryana, India
2 Department of Oral and Maxillofacial Surgery, Manav Rachna Dental College, Faridabad, Haryana, India

Correspondence Address:
Jaishree Sharma
856, Dr. Mukherjee Nagar, Delhi - 110 009
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijpm.ijpm_31_21

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Aim: To evaluate the expression of E-cadherin (E-cad) in oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). Material and Method: Immunohistochemistry was used to detect E-cad expression in 20 cases each of normal oral mucosa, oral epithelial dysplasia and squamous cell carcinoma. Statistical Analysis Used: Inferential statistical methods for statistical analysis used were Chi-square test for comparison of the frequency between different severity of dysplasia and OSCC. Results: Upon assessing the expression of E-cad in OED and OSCC, increase in E-cad immunoreactivity was seen in early lesions. However, the expression of E-cad decreased significantly as the grade of dysplasia increased. Conclusion: We observed a significant decrease in E-cad expression from dysplasia to poorly differentiated squamous cell carcinoma suggesting that loss of expression of E-cad is closely related to carcinoma.

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