Indian Journal of Pathology and Microbiology
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Year : 2022  |  Volume : 65  |  Issue : 3  |  Page : 702-704

Thrombotic thrombocytopenic purpura as an acute complication of COVID-19

Department of General Medicine, D. M. Wayanad Institute of Medical Sciences, Wayanad, Kerala, India

Correspondence Address:
Aneesh Basheer
D. M. Wayanad Institute of Medical Sciences, Wayanad - 673 577, Kerala
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijpm.ijpm_774_21

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Introduction: While disseminated intravascular coagulation (DIC) is a serious complication of COVID-19, a close differential in critically ill patients with thrombocytopenia is Thrombotic thrombocytopenic purpura (TTP). Case Report: We describe the case of a middle-aged lady admitted with COVID-19 pneumonia who developed progressive thrombocytopenia, altered sensorium and renal failure. The absence of coagulation abnormalities alerted to the possibility of TTP, strengthened by presence of schistocytes in peripheral smear. Conclusions: This case highlights the need for high index of suspicion and to pay attention to normal tests as well that might give clues to the diagnosis. New onset thrombocytopenia in COVID-19 need not always indicate DIC. A careful examination of peripheral smear may help diagnosing TTP especially if coagulation profile is normal.

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