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Indian Journal of Pathology and Microbiology
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Year : 2022  |  Volume : 65  |  Issue : 3  |  Page : 653-656

Pathological changes in COVID-19 pneumonia on limited post-mortem sampling of lung: A saga of inflammation and thrombosis


1 Department of Pulmonary Medicine, AIIMS Bhopal, Bhopal, Madhya Pradesh, India
2 Department of CTVS, AIIMS Bhopal, Bhopal, Madhya Pradesh, India
3 Department of Pathology and Lab Medicine, AIIMS Bhopal, Bhopal, Madhya Pradesh, India
4 Department of Anesthesia, AIIMS Bhopal, Bhopal, Madhya Pradesh, India

Correspondence Address:
Garima Goel
Department of Pathology and Lab Medicine, AIIMS Bhopal Saket Nagar, Bhopal - 462 024, Madhya Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/IJPM.IJPM_1158_20

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We describe three postmortem open lung-biopsy findings among patients with COVID-19 pneumonia who were on anticoagulant therapy. The spectrum of histopathological findings included lung inflammation in the form of diffuse alveolar damage (DAD) in exudative and organizing phases, with or without pulmonary artery thrombosis in different stages of evolution. This spectrum of inflammation and thrombosis may be indicative of a natural history of severe COVID-19 pneumonia or demonstrative of variation in therapeutics.


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