Indian Journal of Pathology and Microbiology
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Year : 2021  |  Volume : 64  |  Issue : 4  |  Page : 644-650

Experimental study on the effect of Si and P ion content in SiO2 exposure environment on the degree of pulmonary fibrosis

Department of Respiratory Medicine, Xuzhou Mining Group General Hospital; Department of Respiratory Medicine, Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, China

Correspondence Address:
Haiquan Li
Xuzhou Mining Group General Hospital, #32 Meijian Road, Xuzhou, Jiangsu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/IJPM.IJPM_433_20

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Background: Silicosis is a public health issue in developing countries for long and cannot be completely cured. Objective: To study the changes of ion content with TNF-α and TGF-β expression in alveolar lavage fluid (BALF) at different time points in rats exposed to silica and to investigate their correlation with pulmonary fibrosis. Methods: 42 rats were randomly divided into control group (n = 12) and exposure group (n = 30). Tissues of right lower lungs were collected and fixed for further Hematoxylin-eosin (HE) and Masson staining. We collected the BALF to examine the inflammatory cytokines of TNF-α and TGF-β and measured the ion contents in BALF. Results: The increase of TNF-α level was earlier than TGF-β. The content of silica in BALF was significantly increased after exposure and reached the maximum at 7th day, similar to the curve of cytokine TGF-β level. However, phosphorus ions increased quickly after gradual decline of silicon ion and roughly proportional to the curve of degree of fibrosis. Conclusions: Crystalline silica exposure can cause changes in TGF-β and TNF-α in BALF and accompanied with fibrosis and ions content variation. The abnormal expression of phosphorus ion may have significance in the occurrence and development of silicosis.

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