Indian Journal of Pathology and Microbiology
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Year : 2021  |  Volume : 64  |  Issue : 1  |  Page : 174-176

Mixed endocervical adenocarcinoma and high-grade neuroendocrine carcinoma of the cervix: A case report

Department of Pathology, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey

Correspondence Address:
Gizem Teoman
Department of Pathology, Karadeniz Technical University Faculty of Medicine, 61030 Trabzon
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/IJPM.IJPM_1006_19

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Adenocarcinoma admixed with neuroendocrine carcinoma of the uterine cervix is a rare malignancy with a poor prognosis. In the literature, there are few reported cases. Herein, we report a case of a 56-year-old Turkish woman with cervical adenocarcinoma admixed with small cell neuroendocrine carcinoma. Histological examination of endocervical curettage specimens revealed a tumor composed of almost equal areas of small cell neuroendocrine carcinoma and adenocarcinoma. Neuroendocrine differentiation was confirmed by immunohistochemistry for chromogranin-A, synaptophysin, and CD 56. After the adenocarcinoma and small cell neuroendocrine carcinoma association was detected in the curettage material, both cervicovaginal smear and then total abdominal hysterectomy and bilateral salpingo-oophorectomy resection material of the patient were submitted to our pathology department. Histological features of both curettage and resection material were determined by immunohistochemical studies.

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