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| Year : 2020 | Volume
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| Issue : 5 | Page : 1-2 |
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| From Editor's desk |
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Ranjan Agrawal
Department of Pathology, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh, India
Click here for correspondence address and email
| Date of Web Publication | 26-Feb-2020 |
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How to cite this article:
Agrawal R. From Editor's desk. Indian J Pathol Microbiol 2020;63, Suppl S1:1-2 |
This year we planned to take out a Special Issue 1 of Indian Journal Pathology and Microbiology (IJPM) besides the routine quarterly issues. The topic selected was “Genito urinary and Gynaecologic Pathology including Breast.” The reason behind selecting these subheads was to give a wider coverage and also to have a better overview of this specialty in one place. The idea of publishing a Special Issue 1 of IJPM on these particular topics came to my mind while sending the articles for peer review. The in surge of the articles received was majorly related to these topics. This made me ponder that the main theme of research is in these fields maybe due to an increase in the number of cases or to the better diagnostic approach. Incredible scientific progress invokes not only an interest among the readers but also incites them into carrying out similar activities. The topics have been aptly short listed. There were a good number of articles received and of high standard. Depending on the response we would plan further such Special Issue 1s on burning topics that would be of interest for our existing as well as new readers.
Impact factor of a journal depicts its status amongs tother journals in the field. However, it does not imply that journals with a lower impact factor are inferior in any way. It is only that the articles published in these journals are cited less. It is my sincere request to all the distinguished readers and authors to cite articles published in IJPM whenever they plan to publish articles in any journal.
Breast is one organ where continuous research is going on. Articles on breast pathology are being regularly submitted in IJPM. Carcinoma breast shows tumour budding that has a more aggressive nature with a poor outcome. Kumarguru et al. in their article have suggested inclusion of tumour budding as a parameter while reporting cases of invasive carcinoma breast.[1] Similarly, for patients of carcinoma breast tumor stroma ratio on trucut biopsy specimens determines the response to neoadjuvant therapy especially since it is easy, quick and cost-effective.[2] Role of molecular markers in breast carcinoma is well known. Semi–quantification of ER level using H–score is available. Azami et al. reported an increasing number of patients with low levels of ER, especially seen in Her 2/neu negative women with invasive breast carcinoma.[3] Over expression of Her-2/Neu carries a poor prognosis. Gheni et al. have stressed that estimation of this amplification process is important to determine the prognosis, recurrence and the treatment response. They further reported that IHC can be employed as the initial screening test while qPCR can actually quantify the results and should be used during routine reporting.[4]
Dedifferentiated endometrioid carcinoma exhibits a dual pattern confirmed on IHC staining separate in the undifferentiated part and different in the glandular part. Article by Boler et al exhibits this dual pattern.[5] Kaur et al in their article have mentioned about a unique neoplastic group that have different morphological and immunophenotypic features in which the uterine tumours resemble ovarian sex cord tumours. These entities hold importance as there is a close mimicking with both malignant as well as benign neoplasias.[6]
Role of ER and PR receptors has now been incorporated in routine reporting patterns. However, Bera et al have reported the role of ER and PR in carcinogenesis of prostate. The authors detected expression of both these markers to be lower in prostatic malignancy as compared to the benign lesions.[7] The Gleason scoring system takes its name from Donald Gleason, a pathologist at the Minneapolis Veterans Affairs Hospital, who along with his team members started this scoring system for carcinoma prostate in the 1960s. Gleason's scoring and grading system has since been used in routine carcinoma prostate reporting with subsequent modifications over a period of time. Dere et al. have in their publication debated on the issue of inter-observer variations with the present reporting criterias.[8] Use of Prostein has been recommended by Rao et al in carcinoma prostateso as to increase the sensitivity and specificity in comparison to PSA marker. They further suggested to include it as a panel along with PSA especially in the poorly differentiated and metastatic cases.[9]
As the Editor-in-Chief I thank all those who have contributed directly or indirectly to the completion of this Special Issue 1 of IJPM. We plan to come up with such Special Issue 1s from time to time. I request all my readers to send us their feedback as well as any suggestion for making IJPM much better and reach more heights.
Wishing you all a Happy reading.
 References | |  |
| 1. | Kumarguru BN, Ramaswamy AS, Shaik S, Karri A, Srinivas VS, Prashant BM. Tumor budding in invasive breast cancer - An indispensable budding touchstone. Indian J Pathol Microbiol 2020;63(Spl Issue):S117-22.  |
| 2. | Mallya V, Singh V, Kaur N, Yadav P, Mandal S, Khurana N, et al. Does tumor stroma ratio of breast cancer trucut biopsy determine response to neoadjuvant therapy? Indian J Pathol Microbiol 2020;63(Spl Issue):S113-6. |
| 3. | Azami A, Madani SH, Khazaei S, Izadi B, Saleh E, Sajadimajd S. Survey of low ER-positive expression and its correlation with other clinical and pathological factors in breast cancer. Indian J Pathol Microbiol 2020;63(Spl Issue):S129-33. |
| 4. | Gheni N, Westenberg D. Quantitative realtime PCR assay with immunohistochemical evaluation of HER2/neu oncogene in breast cancer patients and its correlation to clinicopathological findings. Indian J Pathol Microbiol 2020;63(Spl Issue):S123-8. |
| 5. | Boler AK, Akhtar S, Bandyopadhyay A, Roy S. A report of two cases of dedifferentiated endometrioid carcinoma: A newly described underrecognized tumor of poor prognosis. Indian J Pathol Microbiol 2020;63(Spl Issue):S91-3. |
| 6. | Kaur K, Rajeshwari M, Gurung N, Kumar H, Sharma MC, Yadav R, et al. Uterine tumor resembling ovarian sex cord tumor: A series of six cases displaying varied histopathological patterns and clinical profiles. Indian J Pathol Microbiol 2020;63(Spl Issue):S81-6. |
| 7. | Bera KN, Yadav SK, Prakash O, Singh S, Sarin N. Immunoexpression of estrogen receptorβ and progesterone receptor in prostate adenocarcinoma, does it inhibits neoplastic proliferation and invasion? Indian J Pathol Microbiol 2020;63(Spl Issue):S30-3. |
| 8. | Dere Y, Çelik ÖI, Çelik SY, Ekmekçi S, Evcim G, Pehlivan F, et al. A grading dilemma; Gleason scoring system: Are we sufficiently compatible? A multi center study. Indian J Pathol Microbiol 2020;63(Spl Issue):S25-9. |
| 9. | Garudadri G, Rao BV, Sundaram C, Fonseca D, Murthy SS, Sharma R, et al. Diagnostic utility of immunohistochemical marker prostein for evaluation of primary and metastatic prostatic carcinomas. Indian J Pathol Microbiol 2020;63(Spl Issue):S18-24. |
Correspondence Address:
Ranjan Agrawal
Department of Pathology, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0377-4929.279555
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