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| Year : 2019 | Volume
: 62
| Issue : 4 | Page : 521-522 |
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| From Editor's desk |
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Ranjan Agrawal
MD; FIC Path; MIAC, DHA, Professor, Department of Pathology, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh, India
Click here for correspondence address and email
| Date of Web Publication | 14-Oct-2019 |
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How to cite this article:
Agrawal R. From Editor's desk. Indian J Pathol Microbiol 2019;62:521-2 |
Dear Readers,
First of all, welcome to the festive season starting now. The October issue is well within the time frame. Like the previous three regular issues, the present issue contains a compilation of articles of interest for the readers. I request the authors to submit their valuable manuscripts to IJPM. The quality of any journal is metered by its impact factor, which is influenced by the citations of the articles published in it. Good quality articles are highly cited, thus enhancing the impact factor. In this step further, we are soon coming out with a special issue on “Genito-urinary and gynaecological pathology including breast.” This particular issue would include articles related to these specialties only.
There are three articles on oral malignancies. Use of p16 as an immunomarker for squamous cell carcinoma has been documented by Sudhakaran et al. They have further emphasized that p16 shows a variable pattern of expression in benign and malignant lesions.[1] Nishat and Kumar have demonstrated the superior role of Picrosirius red in comparison to van Gieson stain. In addition, increase in perpendicular Type III fibers and advancing histopathological grades suggest the role of collagen fibers in fibrosis.[2] The third article by Kulkarni et al. based on high-throughput omics technologies has stressed that members of both laminin and integrin families play a vital role in cell–extracellular matrix adhesion, leading to metastasis of tumors.[3]
Differentiating keratoacanthoma from well-differentiated squamous cell carcinoma is very important. At times, it is very difficult in making this distinction. Judicious use of p53, Ki-67, and laminin may help in this regard. Turan et al. have meticulously emphasized on the role of these immunohistochemical markers.[4] Chen et al. in their research article showed that c-Cbl is downregulated in cancer stomach as against the normal. This observation may serve as an important finding in the development and progression of gastric cancer.[5]
As per the Bethesda classification of 2017, thyroid cytology has been divided into six different categories. Of these, atypia of undetermined significance is a mixed category with a high risk of turning into malignancy. Ranking each case into different category increases the selection of cases likely to turn malignant, thus helping in the better management of patients. Thakur et al. in their research have diligently highlighted these features.[6]
Advanced cases of adenocarcinoma lung present with malignant pericardial effusions. These effusions when tested by preparing cell blocks and further subjected to molecular markers helped clinicians in determining anticancer drugs. Zhou et al. have emphasized in their study the role of pericardial fluid both for the morphological characters and molecular profiling.[7] Similarly, Rastogi et al. in their article have mentioned the role of high-fluorescence body parameter by automated analyzers as an important screening tool in screening for malignant cases. However, they further emphasized on further validation of this test.[8]
I further request all the readers to make IJPM their first-choice journal and submit more and more articles, especially original research work. I wish you a happy reading.
 References | |  |
| 1. | Sudhakaran A, Hallikeri K, Babu B. p16 as an independent marker for detection of high-risk HPV in oral submucous fibrosis and oral squamous cell carcinoma. Indian J Pathol Microbiol 2019;62:523-8.  [Full text] |
| 2. | Nishat R, Kumar H. Collagen fibers in oral submucous fibrosis-A polarizing microscopy study using two special stains. Indian J Pathol Microbiol 2019;62:537-43. [Full text] |
| 3. | Kulkarni S, Abdulla R, Jose M, Adyanthaya S, Rex AB, Patil A, et al. Omics data-driven analysis identifies laminin-integrin-mediated signaling pathway as a determinant for cell differentiation in oral squamous cell carcinoma. Indian J Pathol Microbiol 2019;62:529-36. [Full text] |
| 4. | Turan G, Altun E, Aslan F, Külahcı Ö. The role of p53, Ki-67 and laminin expression in the differential diagnosis of keratoacanthoma and well-differentiated SCC. Indian J Pathol Microbiol 2019;62:561-5. [Full text] |
| 5. | Chen C, Hui Y, Chen Y, Qian C, Sun M. Loss of c-Cbl expression correlates with de-differentiation status and lymphatic metastasis in gastric cancer. Indian J Pathol Microbiol 2019;62:549-55. [Full text] |
| 6. | Thakur A, Sarin H, Kaur D, Sarin D. Risk of malignancy in thyroid “atypia of undetermined significance/follicular lesion of undetermined significance” and its subcategories – A 5-year experience. Indian J Pathol Microbiol 2019;62:544-8. [Full text] |
| 7. | Zhou B, Li L, Shi D, Jiang T, Xue G, Xiong J. Morphological characterization and molecular profiling of malignant pericardial effusion in patients with pulmonary adenocarcinoma. Indian J Pathol Microbiol 2019;62:566-71. [Full text] |
| 8. | Rastogi L, Dass J, Arya V, Kotwal J. Evaluation of high-fluorescence body fluid (HF-BF) parameter as a screening tool of malignancy in body fluids. Indian J Pathol Microbiol 2019;62:572-7. [Full text] |
Correspondence Address:
Ranjan Agrawal
Department of Pathology, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0377-4929.269091
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