Indian Journal of Pathology and Microbiology
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Year : 2019  |  Volume : 62  |  Issue : 2  |  Page : 283-286

Rare association of cyclopia with craniospinal rachischisis

Department of Pathology, Shri B. M. Patil Medical College, Hospital and Research Centre, Bijapur, Karnataka, India

Correspondence Address:
Lynda D Rodrigues
Department of Pathology, BLDE (Deemed to be University), Shri B. M. Patil Medical College, Hospital and Research Centre, Vijayapur - 586 103, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/IJPM.IJPM_275_17

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Cyclopia is a severe form of holoprosencephaly which results in children being born with just one eye, absence of nose and presence of a proboscis above the median eye. Incidence of cyclopia is around 1.05 in 1, 00,000 births, including stillbirths. The association of anencephaly with spinal rachichisis varies from 17-50%. However, the existence of cyclopia with anencephaly and spinal rachischisis has been reported only in 9 cases till date. We report one more case of cyclopia with anencephaly and spinal rachischisis. Awareness of this spectrum of association with cyclopia, albeit rare, will help in early antenatal diagnosis by fetal ultrasonography. Public education and strict adherence to folic acid supplementation can prevent this unfortunate anomaly.

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