Indian Journal of Pathology and Microbiology
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Year : 2014  |  Volume : 57  |  Issue : 4  |  Page : 591-594

Central nervous system mycosis: Analysis of 10 cases

1 Department of Laboratory Medicine, Sahara Hospital, Lucknow, India
2 Department of Pathology, Sanjay Gandhi Postgraduate Medical Sciences, Lucknow, India
3 Department of Neurosurgery, Sahara Hospital, Lucknow, India
4 Department of Neurosurgery, Vivekananda Polyclinic and Institute of Medical Sciences, Lucknow, India

Correspondence Address:
Anju Shukla
Departments of Laboratory Medicine, Sahara Hospital, Viraj Khand, Gomtinagar, Lucknow
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0377-4929.142678

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Aim: To describe the clinicopathological features in patients with fungal infections of the central nervous system (CNS) presenting as mass lesions. Materials and Methods: A retrospective analysis of records obtained from 10 patients was done with histopathologically confirmed fungal infections presenting as ICSOL, diagnosed in the department of pathology. Clinical features at presentation, findings of radiological investigations performed and histopathology were noted for each patient and subjected for analysis. Results: Infection was higher in males, and paranasal sinusitis was the most common predisposing factor. Location was intraparenchymal followed by sphenoid wing. Four dural-based lesions mimicked meningioma clinically. The most common fungus identified was zygomycosis (seven cases), followed by phaeohyphomycosis (two cases) and aspergillosis (one case). Conclusion: There is a rising trend of CNS mycosis, both in immunocompromised and immunocompetent patients. Intracranial fungal granuloma may mimic radiologically as glioma or meningioma, therefore a high index of suspicion is needed to detect early CNS fungal infections, especially in immunocompetent young patients with no predisposing illness. Fungi should always be excluded in patients with inflammatory or granulomatous pathology of CNS.

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