Indian Journal of Pathology and Microbiology
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Year : 2013  |  Volume : 56  |  Issue : 4  |  Page : 446-448

T-lineage acute lymphoblastic leukemia and parvovirus infection in a child with neurofibromastosis-1

1 Department of Pathology, PGIMER, Chandigarh, India
2 Department of Hematology, PGIMER, Chandigarh, India
3 Department of Pediatrics, PGIMER, Chandigarh, India

Correspondence Address:
Shano Naseem
Department of Hematology, PGIMER, Chandigarh - 160 012
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0377-4929.125366

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Neurofibromatosis (NF-1) patients have an increased risk of developing malignancies most commonly rhabdomyosarcomas, optic gliomas, brain tumors and non-lymphocytic leukemias. Acute lymphoblastic leukemia (ALL) has been infrequently reported in association with NF-1. We describe a rare association of NF-1, T-lineage ALL and parvovirus infection in a 12-year-old child. In addition, it is also to emphasize that a high index of suspicion should be kept for parvovirus B19 infection as a cause of bicytopenia/pancytopenia in ALL patients following induction chemotherapy.

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