Indian Journal of Pathology and Microbiology
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Year : 2011  |  Volume : 54  |  Issue : 3  |  Page : 594-596

Hemophagocytic syndrome associated with Plasmodium falciparum infection

1 Department of Pediatrics, Sri Ramachandra Medical College, Chennai, India
2 Department of Pathology, Sri Ramachandra Medical College, Chennai, India

Correspondence Address:
Julius Xavier Scott
Department of Pediatrics, Sri Ramachandra Medical College, Porur, Chennai - 600 116
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0377-4929.85105

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Hemophagocytic syndrome (HPS) has been associated with infections, hematological malignancies and autoimmune conditions. Malaria is rarely reported to cause HPS. We report a case of an 11-month-old infant with fever, hepatosplenomegaly, pancytopenia, high serum ferritin, hypertriglyceridemia, and bone marrow hemophagocytosis, consistent with hemophagocytic syndrome. Gametocytes of plasmodium falciparum were identified on bone marrow aspiration. Rapid recovery was observed after treatment with antimalarials.

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