|
|
| Year : 2010 | Volume
: 53
| Issue : 1 | Page : 197-198 |
|
| Xanthogranulomatous oophoritis associated with primary infertility and endometriosis |
|
|
Shailaja Shukla, Mukta Pujani, Sanjeet Kumar Singh, Meenu Pujani
Department of Pathology, Lady Hardinge Medical College and Smt. Sucheta Kriplani Hospital, New Delhi, India
Click here for correspondence address and email
| Date of Web Publication | 19-Jan-2010 |
|
|
 |
|
How to cite this article:
Shukla S, Pujani M, Singh SK, Pujani M. Xanthogranulomatous oophoritis associated with primary infertility and endometriosis. Indian J Pathol Microbiol 2010;53:197-8 |
How to cite this URL:
Shukla S, Pujani M, Singh SK, Pujani M. Xanthogranulomatous oophoritis associated with primary infertility and endometriosis. Indian J Pathol Microbiol [serial online] 2010 [cited 2023 May 30];53:197-8. Available from: https://www.ijpmonline.org/text.asp?2010/53/1/197/59240 |
Sir,
Xanthogranulomatous inflammation is a well documented histopathological entity in the gall bladder and kidney. However, xanthogranulomatous inflammation of the female genital tract is unusual and essentially limited to the endometrium. Only a few cases involving the ovary have been reported. [1],[2] We report a case of a 42-year-old married female who was being investigated for primary infertility for the last 10-12 years. On diagnostic laparoscopy, which was performed 10 years back, endometriosis involving the bladder, uterus and uterosacral ligaments was discovered. Subsequently, the patient developed heaviness and pain in the lower abdomen. She had amenorrhea of four months duration and irregular cycles in the preceding eight to 10 months. Per abdominal examination revealed a midline, non tender, cystic mass arising from pelvis going above umbilicus, about the size of a 26-week uterus. Results of laboratory investigations were - hemoglobin 9.8gm%, total leukocyte count 10,000/cumm, erythrocyte sedimentation rate 58mm in first hour, urine microscopic examination - pus cells 5-6/high power field, urine pregnancy test negative.
Ultrasound revealed a large cystic mass measuring 156x108 mm arising from the pelvis and extending till the epigastric region with homogenous low level interstitial echoes, surrounded by a thick wall, it was suggestive of a right ovarian mass (mucinous cystadenoma). Computerized tomography (CT) pelvis revealed a rounded, aseptate, unilocular cystic mass seen in the right adnexal area with thick enhancing walls and homogenous low density fluid contents reaching up to the level of umbilicus. No mural/luminal solid area/calcification seen. An impression of right ovarian cyst was given. Serum CA-125 level was 81.96U/ml. Polymerase chain reaction for M. tuberculosis was negative.
The patient underwent exploratory laparotomy with total abdominal hysterectomy with bilateral salpingo-oophorectomy and omentectomy. Per operatively, a huge ovarian cyst measuring 18x15cm was seen with adhesions to parietal wall and gut loops. Cyst was filled with foul smelling purulent material. Cyst contents were sent for culture and grew Escherichia More Details coli.
Grossly, the right ovarian cyst measured 14x10x4cm and was filled with foul smelling, dirty yellowish fluid. Cyst was unilocular and inner lining was grey brown, shaggy with yellowish nodular surface [Figure 1]. Wall thickness varied from 0.5 to 1cm. The specimen of uterus and cervix with left sided adnexa measured 6x5x3cm. On sectioning, two intramural and one subserosal leiomyomata were identified. Microscopic examination of the cyst wall revealed replacement and destruction of ovarian stroma by inflammatory exudate comprising sheets of foamy macrophages, lymphocytes, plasma cells and some neutrophils [Figure 2]. Microsections from bilateral tubes and left ovary were unremarkable. A diagnosis of xanthogranulomatous oophoritis was established.
Xanthogranulomatous inflammation of the female genital tract is very rare and only a few cases of xanthogranulomatous oophoritis have been reported from India. [3],[4],[5] The involved ovary is usually replaced by a solid, yellow, lobulated mass that is well circumscribed, sometimes involving adjacent organs, thereby mimicking malignancy. [1],[2]
Xanthogranulomatous oophoritis has an uncertain etiopathogenesis. Various factors implicated are chronic bacterial infection with E. coli, Proteus and Staphylococcus aureus, inadequate antibiotic therapy, endometriosis and intrauterine contraceptive device. [3] In the present case, the culture was positive for E.coli  . A difficult differential diagnosis is from malakoplakia. [1] However, in the index case no Michaelis-Gutmann bodies were found on periodic acid Schiff (PAS) staining. The treatment of choice for xanthogranulomatous oophoritis is oophorectomy.
Since xanthogranulomatous oophoritis is usually associated with pelvic inflammatory disease (PID), endometriosis, intrauterine death etc., these patients should be followed up closely. Although a correct diagnosis is made chiefly through histology, a suggestive preoperative diagnosis of xanthogranulomatous oophoritis could lead to less radical surgery.
 References | |  |
| 1. | Ladefoged C, Lorentzen M. Xanthogranulomatous inflammation of the female genital tract. Histopathology 1988;13:541-51.  [PUBMED] [FULLTEXT] |
| 2. | Pace EH, Voet RL, Melancon JT. Xanthogranulomatous oophoritis- an inflammatory pseudotumor of the ovary. Int J Gynecol Pathol 1984;3:398-402. [PUBMED] [FULLTEXT] |
| 3. | Naik M, Madiwale C, Vaideeswar P. Xanthogranulomatous oophoritis- a case report. Indian J Pathol Microbiol 1999;42:89-91. [PUBMED]  |
| 4. | Punia RS, Aggarwal R, Amanjit, Harsh Mohan. Xanthogranulomatous oophoritis and salpingitis: late sequelae of inadequately treated staphylococcal PID. Indian J Pathol Microbiol 2003;46:80-1. |
| 5. | Hemalatha AL, Rao S, Deepak KB, Gayathri MN, Manjunath BS, Rathna S. Xanthogranulomatous salpingo-oophoritis: a rare entity at an exceptional site. Indian J Pathol Microbiol 2007;50:607-9. [PUBMED] |
Correspondence Address:
Mukta Pujani
Department of Pathology, Lady Hardinge Medical College and Smt. Sucheta Kriplani Hospital, New Delhi-110 001
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0377-4929.59240
[Figure 1], [Figure 2] |
|
| This article has been cited by | | 1 |
Xanthogranulomatous endometritis with unilateral salpingo-oophoritis in a postmenopausal woman masquerading as a malignancy |
|
| Kavya Anandathirtha, Zulfiya Shabnam, Lakshmi Manjeera, Nikita Ramesh | | BMJ Case Reports. 2023; 16(1): e247341 | | [Pubmed] | [DOI] | | | 2 |
Xanthogranulomatous inflammation caused by K. pneumonia and nocardiosis mimicking a uterine tumor and invading the ureter and colon: A case report and review of the literature |
|
| Ting-An Shen, Yung-Hsiang Hsu, Dah-Ching Ding | | Taiwanese Journal of Obstetrics and Gynecology. 2022; 61(5): 889 | | [Pubmed] | [DOI] | | | 3 |
Xanthogranulomatous Oophoritis in the Setting of Post-IVF Twin Pregnancy with History of Endometriosis: A Rare Case Report with Review of Literature |
|
| Chinmay Shrikrishna Pendharkar, Sunita B.S, Ganesh Pendkur, Dheeraj J. Nandagawe | | Indian Journal of Medical and Paediatric Oncology. 2022; 43(03): 314 | | [Pubmed] | [DOI] | | | 4 |
Female Genital Tract Affected by Xanthogranulomatous Inflammation: A Series of Four Cases and Review of Literature |
|
| Sunesh Kumar, Kallol K Roy, Richa Vatsa, Jyoti Meena | | Journal of Postgraduate Medicine, Education and Research. 2019; 53(4): 160 | | [Pubmed] | [DOI] | | | 5 |
Xanthogranulomatous salpingitis and oophoritis associated with endometriosis and uterine leiomyoma presenting as intestinal obstruction |
|
| Prabath K. Abeysundara,Goluhewage S. Padumadasa,Warnakulasooriya G. M. Tissera,Prasantha S. Wijesinghe | | Journal of Obstetrics and Gynaecology Research. 2012; 38(8): 1115 | | [Pubmed] | [DOI] | |
|
|
|
|
|
|
|
|
|
|
|
|
| Article Access Statistics | | | Viewed | 4373 | | | Printed | 122 | | | Emailed | 1 | | | PDF Downloaded | 185 | | | Comments | [Add] | | | Cited by others | 5 | | |
|
|
