Indian Journal of Pathology and Microbiology
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Year : 2009  |  Volume : 52  |  Issue : 4  |  Page : 537-539

Coexistent gastric primary choriocarcinoma and adenocarcinoma

1 Department of Pathology, Kasturba Medical College, Mangalore, Karnataka, India
2 Department of Surgery, Kasturba Medical College, Mangalore, Karnataka, India

Correspondence Address:
Alka M Mathai
Department of Pathology, Kasturba Medical College, P.O. Box 53, Mangalore - 575 001, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0377-4929.56155

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Choriocarcinomas are commonly gestational and intrauterine or gonadal in origin. Nongestational and extragonadal disease, especially in the stomach is extremely rare with a poorer prognosis and early metastasis. We herein describe a case of primary gastric choriocarcinoma with liver metastasis in a 69-year-old male. The patient presented with abdominal pain and irregular bowel habits of one month duration. Both endoscopic and radiographic imaging revealed an ulcerated and necrotic circumferential tumor in the pyloric antrum of the stomach. The histopathologic findings of the resected tumor were that of an extensively necrotic and hemorrhagic neoplasm with combined choriocarcinomatous and adenocarcinomatous element. A strongly positive immunohistochemical staining for β- subunit of human chorionic gonadotropin (β-HCG) in the choriocarcinomatous component and a proper correlation with elevated serum β-HCG levels confirmed the diagnosis.

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