| HISTOPATHOLOGY SECTION - CASE REPORT |
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| Year : 2008 | Volume
: 51
| Issue : 1 | Page : 67-69 |
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Inflammatory pseudotumor of lymph nodes presenting as pyrexia of unknown origin
H Gulwani, P Chopra
Department of Histopathology, Sir Ganga Ram Hospital, New Delhi, India
Correspondence Address:
H Gulwani
Department of Histopathology, Sir Ganga Ram Hospital, New Delhi 110 060
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0377-4929.40403
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Inflammatory pseudotumor (IPT) is an uncommon benign disorder characterized by proliferation of spindle cells, inflammatory cells, and small vessels. The IPT of lymph nodes is a rare cause of lymphadenopathy that usually affects one or two nodal groups. We describe a 27-year-old male presenting with generalized lymphadenopathy, hepatosplenomegaly and fever for 1 year. Histologic examination of lymph node revealed few remnant lymphoid aggregates with marked sclerosis and numerous anastomosing blood vessels in lymph node parenchyma. Interspersed in between the fibrotic bands was a polymorphic infiltrate composed of lymphocytes, plasma cells, eosinophils, and immunoblasts. Also, many histiocytes, multinucleated giant cells some being Langhan's type and at places forming ill-defined granulomas were observed. The presence of granulomas and Langhan's type of giant cells can lead to a misdiagnosis of tuberculosis as was also done in the present case. It is thus not only important to be aware of this rare benign pathologic entity while dealing with a case of lymphadenopathy, but also consider it in the differential diagnosis of granulomatous disease. |
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