Indian Journal of Pathology and Microbiology
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Year : 2006  |  Volume : 49  |  Issue : 4  |  Page : 600-2

Diffuse multifocal chorangiomatosis of the placenta with multiple intestinal stenosis of the fetus : combination of rare causes for nonimmune hydrops fetalis.

Department of Pathology, All India Institute of Medical Sciences, New Delhi

Correspondence Address:
A Chopra
Department of Pathology, All India Institute of Medical Sciences, New Delhi

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Source of Support: None, Conflict of Interest: None

PMID: 17183871

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Non-immune causes of hydrops fetalis are rare but frequently fatal. Identification of the cause for hydrops fetalis is essential to institute therapy. Chorangiomatosis and intestinal stenosis have not been previously reported as aetiological factors for the development of hydrops. We report a fetus born with hydrops associated with both of these conditions. A 1575 gms preterm neonate was born to a multigravida at 31 weeks of gestation. Emergency caesarean section was performed after detection of hydrops by prenatal ultrasonography. Baby had generalized edema at birth and died after 3 days due to progressive heart failure. At autopsy there was generalized edema and effusions. There were multiple stenotic segments in the intestine. Placenta showed numerous chorangiomas varying from 0.2 to 3 cm in diameter, hence diagnosed as diffuse multifocal chorangiomatosis. Examination of the placenta at neonatal autopsy is an essential part of assessment for hydrops fetalis. Chorangiomatosis is a rare and under reported condition which can cause prematurity, intrauterine growth retardation, pre-eclampsia and rarely hydrops fetalis.

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