Indian Journal of Pathology and Microbiology
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Year : 2006  |  Volume : 49  |  Issue : 3  |  Page : 452-4

Disseminated histoplasmosis mimicking laryngeal carcinoma from central India--a case report.

Department of Pathology, Jagjivan Ram Hospital, Mumbai

Correspondence Address:
A M Phatak
Department of Pathology, Jagjivan Ram Hospital, Mumbai

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Source of Support: None, Conflict of Interest: None

PMID: 17001921

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A 58 year old male, chronic smoker, with diabetes mellitus (Type II), residing in Madhya Pradesh presented with dysphagia, hoarseness, odynophagia and significant weight loss. Microlaryngoscopy showed reddish ulcerated area involving valleculae, and pharyngo-epiglottic fold. Histopathological examination showed foamy macrophages containing Histoplasma capsulatum. Patient initially responded to Azoles, relapsed three months after stopping the treatment and presented with oral lesions. Biopsy showed H. capsulatum, histologically as well as on culture. The mycelial phase converted to yeast phase on B.H.I.A. at 37 degrees C confirming the isolate as H. capsulatum. The patient responded well to amphotericin B.

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