Indian Journal of Pathology and Microbiology
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Year : 2001  |  Volume : 44  |  Issue : 3  |  Page : 301-4

Immunochemical studies in Wilson's disease.

Immunochemistry Section, Department of Microbiology, Government Medical College, Nagpur

Correspondence Address:
C Chande
Immunochemistry Section, Department of Microbiology, Government Medical College, Nagpur

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Source of Support: None, Conflict of Interest: None

PMID: 12024917

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The present study deals with a total of 28 cases of Wilson's disease, 50 normal individuals alongwith siblings and parents of eight cases. Male predominance (18 out of 28 cases), a median age of 11 years and universal presence of Kayser-Fleischer (K. F.) ring marked the cardinal features. Furthermore, 11 patients had hepatic-neural presentation while two had only the K. F. Ring without clinical abnormality. Single Radial Immunodiffusion (SRID) as the absolute quantitative procedure revealed a profound deficiency of ceruloplasmin with the levels ranging anywhere between 0.5 mg/dI to 23 mg/dI amongst the patients of Wilson's disease. The data from siblings and parents also revealed deficiency in 15 out of 23 serum samples when subjected to disc electrophoresis-benzidine screening procedure.

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