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| Year : 2001 | Volume
: 44
| Issue : 2 | Page : 163-7 |
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Nerve cell markers in ossifying fibromyxoid tumour of soft parts.
T Shet, S Desai, S Kane, I Vora
Department of Pathology, BYL Nair Ch Hospital, Mumbai
Correspondence Address:
T Shet
Department of Pathology, BYL Nair Ch Hospital, Mumbai
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 11883138 
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Reported herein are two benign ossifying fibromyxoid tumors (OFMTs) of the soft tissues in axilla and terminal phalanx respectively. Both cases on immunohistochemistry (IHC) showed reactivity for vimentin, S-100 protein and glial fibrillary acidic protein (GFAP) antibodies. In addition, a focal/diffuse strong positivity for neurofilament (NF) and neuron specific enolase (NSE) was observed. Electron microscopy in one instance revealed abundant intermediate filaments, primitive cell junctions and a focally present external lamina. In the light of nerve cell differentiation of these tumors and the similarity of IHC profile and EM features of OFMT to a poorly differentiated malignant peripheral nerve sheath tumor (MPNST); it is suggested that OFMT is a variably differentiated PNST rather than a simple Schwannian neoplasm as is believed. |
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