Indian Journal of Pathology and Microbiology
Home About us Instructions Submission Subscribe Advertise Contact e-Alerts Ahead Of Print Login 
Users Online: 4746
Print this page  Email this page Bookmark this page Small font sizeDefault font sizeIncrease font size
Year : 2000  |  Volume : 43  |  Issue : 4  |  Page : 441-7

Immunohistochemical localization of transferrin in human breast cancer tissue.

Department of Pathology, Institute of Clinical Epidemiology King George's Medical College, Lucknow

Correspondence Address:
P K Agarwal
Department of Pathology, Institute of Clinical Epidemiology King George's Medical College, Lucknow

Login to access the Email id

Source of Support: None, Conflict of Interest: None

PMID: 11344609

Rights and PermissionsRights and Permissions

The present study was planned to detect the iron binding protein, transferrin (TR) in paraffin sections of the human breast tumors. The distribution of transferrin has been studied in 153 cases (63 benign lesions and 90 malignant tumors). The extent of staining reaction was determined by semiquantitative grading (weak, moderate and consistent). Positivity rate for transferrin was higher (92.2%) in malignant tumors as compared to benign breast lesions (28.5%) with significant p value (p = 0.0001) for both the groups. The intensity was variable in both the groups, being more intense in the malignant tumors. Tumors with higher grade of malignancy presented consistent positive staining along with the lymph nodes involved. The extent of immunoreactivity revealed a significant positive correlation with axillary lymph node status. However, no significant correlation was found with the age of the patients. Thus the study of transferrin in breast tumors besides being of prognostic significance helps in the further management of malignant lesions of the breast.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded36    
    Comments [Add]    

Recommend this journal