Indian Journal of Pathology and Microbiology
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Year : 1999  |  Volume : 42  |  Issue : 3  |  Page : 345-53

Clinicopathological correlation of diaphragmatic contraction band necrosis in a neonatal and infantile population--an autopsy study.

Department of Pathology, B.J. Medical College, Pune

Correspondence Address:
S Deshmukh
Department of Pathology, B.J. Medical College, Pune

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Source of Support: None, Conflict of Interest: None

PMID: 10862296

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Contraction band necrosis' is a lesion widely studied in myocardial fibres (Heart) and to some extent in skeletal and smooth muscles. The phenomenon of Diaphragmatic Contraction Band necrosis (D-CBN) occurring in the diaphragms of 53 neonates and infants removed at autopsy were studied microscopically. Of these D-CBN was present in 19 (35.85%) cases. D-CBN presented in two morphological patterns (I) solid ('Block-like') segmental necrosis in 31.58% cases or (ii) Ribbon-like transfiber (shredded appearance) bands in 15.79% cases. A combination of both the above lesions were observed in a vast majority of cases, i.e. 52.63% cases. A clinicopathological correlation was attempted as regards cause and mode of death with occurrence and severity of D-CBN. It was found that severe D-CBN was present in the group of birth asphyxia (26.92%) and infant infections (20.0%). The presence and frequency of D-CBN in autopsied subjects proved useful in interpreting the cause and mode of death.

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