Indian Journal of Pathology and Microbiology
Home About us Instructions Submission Subscribe Advertise Contact e-Alerts Ahead Of Print Login 
Users Online: 9395
Print this page  Email this page Bookmark this page Small font sizeDefault font sizeIncrease font size
Year : 1999  |  Volume : 42  |  Issue : 1  |  Page : 31-5

Platelet auto-antibodies in septicaemic patients.

Department of Pathology, J.N. Medical College, AMU Aligarh, U.P

Correspondence Address:
T K Ghosh
Department of Pathology, J.N. Medical College, AMU Aligarh, U.P

Login to access the Email id

Source of Support: None, Conflict of Interest: None

PMID: 10420682

Rights and PermissionsRights and Permissions

Thrombocytopenia associated with acute Septicaemia has been reported which may be due to Disseminated Intravasscular Coagulation (DIC), but has also been reported even without any evidence of it. An immunological cause has been suggested to explain this observation. The present study involved the investigation of 50 patients with clinical and bacteriological evidence of Septicaemia. By Direct Platelet Suspension Immunofluorescence Test (PSIFT) antiplatelet antibodies were detected in 54% patients with septicaemia and 67.5% with those having thrombocytopenia. The septicaemic patients were treated with antibiotics (mean 14 days). After successful treatment, i.e., when there was no bacteriological evidence of septicaemia, there was in increase in the platelet count (> 150 x 10(9)/L) with a corresponding fall in "PSIFT" positivity in 17 cases (P < 0.001). Hence an immunological process is considered to play a significant role in the pathogenesis of thrombocytopenia in these patients with septicaemia.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded58    
    Comments [Add]    

Recommend this journal