|
|
| Year : 1998 | Volume
: 41
| Issue : 4 | Page : 479-84 |
|
|
Hyalinizing trabecular adenoma--a case report with FNAC histologic, MIB-1 proliferative index and immunohistochemical findings.
A K Karak, M Sahoo, D Bhatnagar
Department of Pathology, All India Institute of Medical Sciences, INMAS, New Delhi
Correspondence Address:
A K Karak
Department of Pathology, All India Institute of Medical Sciences, INMAS, New Delhi
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 9866913 
|
|
|
Hyalinizing trabecular adenoma is a recently described benign thyroid tumor, almost exclusively occurring in females. The morphological features of this entity overlap with both papillary and medullary carcinoma to varying extent. This, in turn, creates a situation of serious diagnostic pitfall particularly for a false positive diagnosis of papillary carcinoma in fine needle aspiration (FNA) cytology. False consideration of medullary carcinoma is also possible by the unwary especially if staining for Congo red and/or immunostaining for calcitonin is not resorted to. At histologic level, the distinctive architectural pattern is however of great help and thus poses a much lesser danger of misdiagnosis. We relate here our experience in a recently encountered case of hyalinizing trabecular adenoma and describe detailed FNA cytologic and histologic findings along with immunohistochemical profile using a panel of eight monoclonal antibodies. The tumor proliferative potential has also been assessed using MIB-1 (Ki-67) immunostaining. The various pros and cons of diagnostic pitfalls are discussed. |
|
|
|
| [PDF]* |
|
 |
|
